A Novel Magnetic Carbon Nanotubes Functionalized with Pyridine Groups: Synthesis, Characterization and Their Application as an Efficient Carrier for Plasmid DNA and Aptamer. Issue 24 (25th June 2018)

• Record Type: Journal Article
• Authors: Kaboudin, Babak; Saghatchi, Fatemeh; Kazemi, Foad; Akbari‐Birgani, Shiva
• Is Part Of: ChemistrySelect. Volume 3:Issue 24(2018)
• Page Start: 6743
• Page End: 6749
• Publication Date: 2018-06-25
• Subjects: Aptamer -- Carbon nanotubes -- Gene delivery -- Magnetic nanoparticles -- Plasmid DNA; Chemistry -- Periodicals; 540.5
• DOI: 10.1002/slct.201800708
• Languages: English
• ISSNs: 2365-6549

Abstract

Abstract: Magnetic functionalized multi‐walled carbon nanotubes have been synthesized, characterized and studied for therapeutically active nucleic acids interaction and delivery. In this study, pyridine functionalized magnetically was investigated for plasmid DNA and aptamer delivery. A thorough structural characterization of new carrierhas been carried out by means of transmission electron microscopy, scanning electron microscopy images, carbon, hydrogen and nitrogen elemental analysis, thermogravimetric analysis, vibrating‐sample magnetometer and spectroscopy. The magnetic properties of magnetic functionalized multi‐walled carbon nanotubes allow the directional control of conjugated nucleic acids with a transporter using an external magnetic field. They can be used as a transporter to afford noncovalent binding with nucleic acids and are supposed to cross the plasma membrane and internalize into the cytoplasm without inducing cell death. Abstract : Magnetic functionalized carbon nanotube as a carrier for plasmid DNA and aptamer: A novel magnetic functionalized carbon nanotube with a high capacity of carrying plasmid DNA and aptamer, very low cytotoxicity and fast transfer to the cell. Besides, they have the capability to be guided and recycled using a magnetic field.