Association of pre‐eclampsia with SOD2 Ala16Val polymorphism among mother–father–infant triads. Issue 2 (30th May 2018)

• Record Type: Journal Article
• Authors: Luo, Zhong‐Cheng; Julien, Pierre; Wei, Shu‐Qin; Audibert, Francois; Fraser, William D.
• Is Part Of: International journal of gynaecology and obstetrics. Volume 142:Issue 2(2018)
• Page Start: 221
• Page End: 227
• Publication Date: 2018-05-30
• Subjects: Mother–father–infant triad -- Oxidative stress -- Pre‐eclampsia -- Single‐nucleotide polymorphism -- SOD1 +35A/C -- SOD2 Ala16Val -- Superoxide dismutase; Gynecology -- Periodicals; Obstetrics -- Periodicals; Electronic journals; 618
• DOI: 10.1002/ijgo.12528
• Languages: English
• ISSNs: 0020-7292

Abstract

Abstract: Objective: To determine whether pre‐eclampsia is associated with polymorphisms in superoxide dismutase ( SOD ) genes among mother–father–infant triads. Methods: We did this follow‐up cohort study at 17 urban hospitals in Canada between October 1, 2008, and September 30, 2010. We recruited Canadian participants who had participated in the International Trial of Antioxidant Supplementation for the Prevention of Pre‐eclampsia. Saliva specimens were collected for DNA extraction. The SOD1 +35A/C (rs2234694) and SOD2 Ala16Val C/T (rs4880) single‐nucleotide polymorphisms (SNPs) were genotyped. Results: Dual presence of the SOD2 Ala16Val TT variant among mother–father pairs (n = 657) was associated with an increased risk of pre‐eclampsia when compared with the absence of the TT variant among the mother–father pairs (7/48 [14.6%] vs 11/339 [3.2%]; adjusted odds ratio 6.80, 95% confidence interval 2.32–19.95; P< 0.001). By contrast, presence of a single T variant in mother–father pairs (16/270 [5.9%]) or mother–infant pairs (8/179 [4.5%]) was not associated with pre‐eclampsia. The SOD1 +35A/C SNP was not associated with pre‐eclampsia. Conclusion: The SOD2 Ala16Val SNP might be involved in paternal influence on the maternal predisposition to pre‐eclampsia. Genotyping of mother–father pairs could be a promising strategy to identify pre‐eclampsia genes. Abstract : The Ala16Val polymorphism of superoxide dismutase 2 gene might contribute to the paternal influence on maternal predisposition to pre‐eclampsia.