Bacterial biofilm formation on implantable devices and approaches to its treatment and prevention. Issue 12 (December 2018)

• Record Type: Journal Article
• Authors: Khatoon, Zohra; McTiernan, Christopher D.; Suuronen, Erik J.; Mah, Thien-Fah; Alarcon, Emilio I.
• Is Part Of: Heliyon. Volume 4:Issue 12(2018)
• Publication Date: 2018-12
• Subjects: Microbiology -- Biomedical engineering -- Infectious disease; Research -- Periodicals; Medical sciences -- Periodicals; Natural history -- Periodicals; Social sciences -- Periodicals; Earth sciences -- Periodicals; Physical sciences -- Periodicals; 507.2
• DOI: 10.1016/j.heliyon.2018.e01067
• Languages: English
• ISSNs: 2405-8440

Abstract

Abstract: In living organisms, biofilms are defined as complex communities of bacteria residing within an exopolysaccharide matrix that adheres to a surface. In the clinic, they are typically the cause of chronic, nosocomial, and medical device-related infections. Due to the antibiotic-resistant nature of biofilms, the use of antibiotics alone is ineffective for treating biofilm-related infections. In this review, we present a brief overview of concepts of bacterial biofilm formation, and current state-of-the-art therapeutic approaches for preventing and treating biofilms. Also, we have reviewed the prevalence of such infections on medical devices and discussed the future challenges that need to be overcome in order to successfully treat biofilms using the novel technologies being developed.