Convergent synthesis of diptoindonesin G. Issue 3 (17th January 2019)

• Record Type: Journal Article
• Authors: Singh, Dileep Kumar; Kim, Ikyon
• Is Part Of: Tetrahedron letters. Volume 60:Issue 3(2019)
• Page Start: 300
• Page End: 301
• Publication Date: 2019-01-17
• Subjects: Diptoindonesin G -- Oligostilbenoids -- Natural product -- Suzuki-Miyaura coupling -- Intramolecular reaction -- Friedel-Crafts acylation; Chemistry, Organic -- Periodicals; 547.005
• DOI: 10.1016/j.tetlet.2018.12.036
• Languages: English
• ISSNs: 0040-4039

Abstract

Graphical abstract: Highlights: A convergent and scalable synthetic approach to diptoindonesin G is described. Suzuki-Miyaura coupling and intramolecular Friedel-Crafts acylation as key steps. This route should be useful for synthesis of diptoindonesin G and its derivatives. Abstract: A convergent and scalable synthetic route to a tetracyclic oligostilbenoid natural product, diptoindonesin G, is described where Suzuki-Miyaura cross-coupling and intramolecular Friedel-Crafts acylation were employed to construct the central C ring of diptoindonesin G. Two fragments for cross-coupling reaction were readily synthesized with similar efficiency.