Pharmacokinetic/pharmacodynamic modelling of effective components of Fangji Huangqi Tang for its treatment of nephrotic syndrome. (30th November 2018)

• Record Type: Journal Article
• Authors: Liu, Xiao; Zhu, Xiaochai; Xie, Li; Cai, Baochang
• Is Part Of: New journal of chemistry. Volume 43:Number 1(2019)
• Page Start: 338
• Page End: 347
• Publication Date: 2018-11-30
• Subjects: Chemistry -- Periodicals; Chimie -- Périodiques; 540
• DOI: 10.1039/c8nj03040e
• Languages: English
• ISSNs: 1144-0546

Abstract

Abstract : An interesting study on the underlying correlations between pharmacokinetic parameters and the effective indexes of FHT based on PK-PD model. Abstract : This study was designed to evaluate the potential effective components of Fangji Huangqi Tang for the treatment of nephrotic syndrome based on a pharmacokinetic/pharmacodynamic model. To quantify the relationships between the pharmacokinetics and pharmacodynamics of fangchinoline and tetrandrine, the pharmacokinetic/pharmacodynamic model was set up by combining pharmacokinetic parameters and the effective indexes in rats. Compared with a model group, the effective indexes including serum urea nitrogen, cysteine protease inhibitors C, total cholesterol and triglycerides in the FHT group became significantly lower with a dosing time extension. The pharmacokinetic/pharmacodynamic modeling results showed that there were good linear relationships between the areas under the concentration-time curves and these effective indexes. Finally, fangchinoline and tetrandrine were proved to be the main effective chemical materials of FHT to cure nephrotic syndrome in rats.