A symbiotic supramolecular approach to the design of novel amphiphiles with antibacterial properties against MSRA. Issue 1 (4th December 2018)

• Record Type: Journal Article
• Authors: Tyuleva, Stilyana N.; Allen, Nyasha; White, Lisa J.; Pépés, Antigoni; Shepherd, Helena J.; Saines, Paul J.; Ellaby, Rebecca J.; Mulvihill, Daniel P.; Hiscock, Jennifer R.
• Is Part Of: Chemical communications. Volume 55:Issue 1(2019)
• Page Start: 95
• Page End: 98
• Publication Date: 2018-12-04
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/c8cc08485h
• Languages: English
• ISSNs: 1359-7345

Abstract

Abstract : The co-formulation of supramolecular self-associating amphiphiles (SSAs) enhances solution state physicochemical properties and increases efficacy against methicillin-resistant Staphylococcus aureus . Abstract : Herein, we identify supramolecular self-associating amphiphiles (SSAs) as a novel class of antibacterials with activity towards methicillin-resistant Staphylococcus aureus . Structure–activity relationships have been identified in the solid, solution and gas phases. Finally, we show that when supplied in combination, SSAs exhibit increased antibacterial efficacy against these clinically relevant microbes.