Monoterpenes modulating cytokines - A review. (January 2019)

• Record Type: Journal Article
• Authors: Quintans, Jullyana S.S.; Shanmugam, Saravanan; Heimfarth, Luana; Araújo, Adriano Antunes S.; Almeida, Jackson R.G.da S.; Picot, Laurent; Quintans-Júnior, Lucindo J.
• Is Part Of: Food and chemical toxicology. Volume 123(2019)
• Page Start: 233
• Page End: 257
• Publication Date: 2019-01
• Subjects: Natural products -- Terpenes -- Inflammation -- Cytokines; AP-1 Activator protein 1 -- APP Amyloid precursor protein -- BCG Bacillus Calmétte-Guérin -- βCD β-cyclodextrin -- CFA Complete Freund's Adjuvant -- CT Citronellol -- CTGF Connective tissue growth factor -- DNCB Dinitrochlorobenzene -- DSS Dextran sulfate sodium -- EOs Essential oils -- ERK Extracellular signal-regulated kinase -- FSGS Focal segmental glomerulosclerosis -- GE Geniposide -- GeOH Geraniol -- LPS Lipopolysaccharide -- MCAO Middle cerebral artery occlusion -- MMPs Matrix metalloproteinases -- NKT Natural killer T -- NLRP3 nucleotide-binding domain, leucine-rich-containing family, pyrin domain-containing-3 -- NSAID Nonsteroidal anti-inflammatory drugs -- OVA Ovalbumin -- PA Perillyl alcohol -- PAH Perillaldehyde -- PF Paeoniflorin -- PS1 Presenilin 1 -- RA rheumatoid arthritis -- STAT-1 Activator of transcription 1 -- Th1 T helper 1 cells -- Th2 T helper 2 cells -- TLR Toll Like Receptor -- TNBS Trinitrobenzenesulfonic acid -- TPN α-terpineol -- TQ Thymoquinone -- VEGF Vascular endothelial growth factor; Toxicology -- Periodicals; Food poisoning -- Periodicals; Food Poisoning -- Periodicals; Toxicology -- Periodicals; Toxicologie -- Périodiques; Intoxications alimentaires -- Périodiques; Food poisoning; Toxicology; Periodicals; Electronic journals; 615.9
• DOI: 10.1016/j.fct.2018.10.058
• Languages: English
• ISSNs: 0278-6915

Abstract

Abstract: Inflammatory response can be driven by cytokine production and is a pivotal target in the management of inflammatory diseases. Monoterpenes have shown that promising profile as agents which reduce the inflammatory process and also modulate the key chemical mediators of inflammation, such as pro and anti-inflammatory cytokines. The main interest focused on monoterpenes were to develop the analgesic and anti-inflammatory drugs. In this review, we summarized current knowledge on monoterpenes that produce anti-inflammatory effects by modulating the release of cytokines, as well as suggesting that which monoterpenoid molecules may be most effective in the treatment of inflammatory disease. Several different inflammatory markers were evaluated as a target of monoterpenes. The proinflammatory and anti-inflammatory cytokines were found TNF-α, IL-1β, IL-2, IL-5, IL-4, IL-6, IL-8, IL-10, IL-12 IL-13, IL-17A, IFNγ, TGF-β1 and IFN-γ. Our review found evidence that NF-κB and MAPK signaling are important pathways for the anti-inflammatory action of monoterpenes. We found 24 monoterpenes that modulate the production of cytokines, which appears to be the major pharmacological mechanism these compounds possess in relation to the attenuation of inflammatory response. Despite the compelling evidence supporting the anti-inflammatory effect of monoterpenes, further studies are necessary to fully explore their potential as anti-inflammatory compounds. Graphical abstract: