Genus Tetradium L.: A comprehensive review on traditional uses, phytochemistry, and pharmacological activities. (1st March 2019)

• Record Type: Journal Article
• Authors: Zhao, Zefeng; He, Xirui; Han, Wei; Chen, Xufei; Liu, Peiliang; Zhao, Xue; Wang, Xing; Zhang, Lixin; Wu, Shaoping; Zheng, Xiaohui
• Is Part Of: Journal of ethnopharmacology. Volume 231(2019)
• Page Start: 337
• Page End: 354
• Publication Date: 2019-03-01
• Subjects: AHR aromatic hydrocarbon receptor -- AUC area under the concentration–time curve -- ALP alkaline phosphatase -- AP-1 Activator protein 1 -- AFP alpha fetoprotein -- Ang II angiotensin II -- ACh acetylcholine -- AChE acetylcholinesterase -- AgRP agouti-related protein -- AMPK adenosine 5′-monophosphate (AMP)-activated protein kinase -- ALDH aldehyde dehydrogenase -- ADH alcohol dehydrogenase -- ATP adenosine triphosphate -- BMP-2 bone morphogenetic protein 2 -- BACE1 β-secretase 2QP8 -- BChE butyrylcholinesterase -- CYP hepatic cytochrome P450 -- CL Plasma clearance -- COL1A1 collagen type I alpha 1 chain -- COX-2 cyclooxygenase-2 -- CT105 carboxy-terminal 105 amino acid -- cAMP cyclic adenosine monophosphate -- CGRP calcitonin gene-related peptide -- C/EBP α CCAAT/-enhancer-binding protein alpha -- Cu–Zn SOD Cu–Zn superoxide dismutase -- CytC cytochrome complex -- ± dp/dtmax maximum rate of pressure change in the ventricle -- DHED dehydroevodiamineHCl -- EGFR epidermal growth factor receptor -- E-2 beta-adrenergic receptor -- EC50 50% effective concentration -- ERK extracellular signal-regulated protein kinase -- GC-MS chromatography-mass spectrometry -- GM-CSF granulocyte- macrophage colony-stimulating factor -- GATA-2 GATA-binding protein 2 -- GATA-3 GATA-binding protein 3 -- GPX5 glutathione peroxidase type 5 -- GSH glutathione -- HPLC high-performance liquid chromatography -- HSCCC high-speed countercurrent chromatography -- HWP human white preadipocyte -- IC50 50% inhibitory concentration -- IL-1β interleukin 1 beta -- IL-6 interleukin 6 -- iNOS nitric oxide synthase -- ICR Institute of Cancer Research -- ID50 50% inhibitory dose -- IAV influenza A virus -- JNK c-Jun N-terminal protein kinase -- Loureiro LPS lipopolysaccharide -- LC50 50% lethal concentration -- LD50 50% lethal dose -- MAO monoamine oxidase -- MS mass spectrum -- MRT mean residence time -- MTT 3-(4, 5- dimethyl-2-thiazolyl)-2, 5-diphenyl-2-H-tetrazolium bromide -- MIC minimum inhibitory concentration -- MBC minimum bactericidal concentration -- MDA malondialdehyde -- MPO myeloperoxidase -- MMP mitochondrial membrane potential -- MN methyl nicotinate -- mTOR mechanistic target of rapamycin -- MPT mitochondrial permeability transition -- NO nitric oxide -- NF-κB nuclear factor-kappa B -- NPY neuropeptide Y -- PARP poly(ADP-ribose)polymerase -- PCNA proliferating cell nuclear antigen -- PI3K phosphoinositide 3-kinase -- PPAR γ peroxisome proliferator-activated receptor γ -- PCA passive cutaneous anaphylaxis -- RUNX2 runt-related transcription factor 2 -- ROS reactive oxygen species -- SOD superoxide dismutase -- SREBP-1c sterol- regulatory element-binding protein -- TRPV1 transient receptor potential vanilloid-1 -- TopoI DNA topoisomerase I -- T1/2 half-life period -- TPA 12-O-tetradecanoylphorbol-13-acetate -- TSC2 tuberous sclerosis 2 -- TPA 12-O- tetradecanoylphorbol-13-acetate -- TSGF tumor specific growth factor -- TNF-α tumor necrosis factor alpha -- Vd apparent volume of distribution -- Ver veratridine -- VCD 4-vinylcyclohexene diepoxide -- ZJP Zuo Jin Pian; Tetradium L. -- Evodiamine -- Antitumor -- Anti-inflammatory -- CNS -- Review; Ethnopharmacology -- Periodicals; Pharmacognosy -- Periodicals; Herbs -- Periodicals; Herbs -- Periodicals; Pharmacognosy -- Periodicals; Pharmacognosie -- Périodiques; Herbes -- Périodiques; 615.1
• DOI: 10.1016/j.jep.2018.11.035
• Languages: English
• ISSNs: 0378-8741

Abstract

Abstract: Ethnopharmacological relevance: The dried fruit of Tetradium ruticarpum is frequently utilized as a common traditional medicine in China, Japan and Korea. It has been widely used for the treatment of various diseases such as headache, menorrhalgia, dermatophytosis, celialgia, emesis and aphtha and so on. Aim of this review: Despite the wide biological activities of Tetradium plants, there is no current review summarizing medicinal properties of the genus of plants; thus, this review aims to systematically summarize studies on botanical characteristics, traditional uses, phytochemical ingredients, quality control, pharmacokinetics, pharmacological activities and toxicity of Tetradium species to demonstrate their therapeutic capacity. Materials and methods: Information and materials related to Tetradium species were obtained from scientific databases such as Google Scholar, Wikipedia, Web of Science, PubMed, ScienceDirect, ACS Publications, SciFinder. Information was also gathered from International Plant Names Index, Global Biodiversity Information Facility, Chinese Pharmacopoeia and Traditional Chinese Medicine classics, etc. All studies of this genus were included in this review until July 2018. Results: Tetradium is widely assessed regarding its phytochemistry and biological activities. Approximately 131 chemical compounds, including alkaloids, saponins, phenols and other compounds, have been isolated from Tetradium plants. Among these components, alkaloid evodiamine is the most representative active ingredients of Tetradium plants. These compounds isolated from Tetradium plants exhibit a wide range of biological activities in vitro and in vivo including antitumor, antibacterial, anti-inflammatory, insecticide, cardioprotective and lipid-lowering, treating CNS disorders, digestive system regulation and endocrine system improving activities. Furthermore, alkaloids could be used as markers for quality identification and evaluation of medicinal materials and their preparations. Information on evaluating the safety and pharmacokinetics of Tetradium often focuses on the alkaloids, thus further study and clinical data are required to enable the drug safety of the utilization of Tetradium plants. Conclusions: Phytochemical and pharmacological studies of Tetradium plants have proved Tetradium plants are important medicinal herb resource. However, well-designed randomized clinical trials are necessary to confirm the therapeutic benefits of this genus in clinical settings.