Facile synthesis of acyl sulfonamides from carboxyic acids using the Mukaiyama reagent. Issue 3 (17th January 2019)

• Record Type: Journal Article
• Authors: Chen, Ling; Luo, Guanglin
• Is Part Of: Tetrahedron letters. Volume 60:Issue 3(2019)
• Page Start: 268
• Page End: 271
• Publication Date: 2019-01-17
• Subjects: Acyl sulfonamides -- Mukaiyama reagent -- Carboxylic acids coupling -- Coupling with sulfonamides -- Acylsulfonamides synthesis; Chemistry, Organic -- Periodicals; 547.005
• DOI: 10.1016/j.tetlet.2018.12.030
• Languages: English
• ISSNs: 0040-4039

Abstract

Graphical abstract: Highlights: Acylsulfonamides were synthesized within 1 h using Mukaiyama reagent(CMPI)/DMAP/TEA method at optimal condition. Method was efficient with broad scope of aryl/heteroaryl and alphatic caboxylic acids. Method tolerated various aliphatic, aryl and heteroaryl sulfonamides. Method was simple to operate at room temperature under atmosphere condition. Abstract: A fast and convenient method using the Mukaiyama reagent was developed to prepare acyl sulfonamides from carboxylic acids and sulfonamides. This methodology is effective for a range of acids and sulfonamides proceeding in moderate to good yields with the majority of reactions complete within one hour under the optimized condition.