An overview of epigenetic agents and natural nutrition products targeting DNA methyltransferase, histone deacetylases and microRNAs. (January 2019)

• Record Type: Journal Article
• Authors: Huang, Deyu; Cui, LuQing; Ahmed, Saeed; Zainab, Fatima; Wu, Qinghua; Wang, Xu; Yuan, Zonghui
• Is Part Of: Food and chemical toxicology. Volume 123(2019)
• Page Start: 574
• Page End: 594
• Publication Date: 2019-01
• Subjects: Epigenetic therapy -- DNMT -- HDAC -- microRNA -- DNA methylation -- Histone modifications; Toxicology -- Periodicals; Food poisoning -- Periodicals; Food Poisoning -- Periodicals; Toxicology -- Periodicals; Toxicologie -- Périodiques; Intoxications alimentaires -- Périodiques; Food poisoning; Toxicology; Periodicals; Electronic journals; 615.9
• DOI: 10.1016/j.fct.2018.10.052
• Languages: English
• ISSNs: 0278-6915

Abstract

Abstract: Several humans' diseases such as; cancer, heart disease, diabetes retain an etiology of epigenetic, and a new therapeutic option termed as "epigenetic therapy" can offer a potential way to treat these diseases. A numbers of epigenetic agents such as; inhibitors of DNA methyltransferase (DNMT) and histone deacetylases (HDACs) have grew an intensive investigation, and many of these agents are currently being tested in a clinical trial, while some of them have been approved for the use by the authorities. Since miRNAs can act as tumor suppressors or oncogenes, the miRNA mimics and molecules targeted at miRNAs (antimiRs) have been designed to treat some of the diseases. Much naturally occurring nutrition were discovered to alter the epigenetic states of cells. The nutrition, including polyphenol, flavonoid compounds, and cruciferous vegetables possess multiple beneficial effects, and some can simultaneously change the DNA methylation, histone modifications and expression of microRNA (miRNA). This review mainly summarizes the information of epigenetic agents of DNMTs and HDACs inhibitors, miRNA mimics and antimiRs, as well as the natural nutrition. In addition, some future perspectives related to the epigenetic therapy are also included. Highlights: "Epigenetic therapy" for several humans' diseases targeting DNMTs, HDACs and miRNAs has been proposed. Many DNMTs and HDACs inhibitors, miRNA mimics and antimiRs are tested in clinical trials. Polyphenol, flavonoid and organosulfur compounds and cruciferous vegetables can modulate epigenetic states. Combined effectiveness of different epigenetic nutrition compounds may achieve a better effect than used alone.