Radiotherapy modality as a predictor of survival in hypopharyngeal cancer. Issue 11 (10th October 2018)

• Record Type: Journal Article
• Authors: Kılıç, Suat; Kılıç, Sarah S; Hsueh, Wayne D; Eloy, Jean Anderson; Baredes, Soly; Woo Park, Richard Chan; Mahmoud, Omar
• Is Part Of: Head & neck. Volume 40:Issue 11(2018)
• Page Start: 2441
• Page End: 2448
• Publication Date: 2018-10-10
• Subjects: cancer -- hypopharynx -- IMRT -- radiation -- radiotherapy -- survival; Head -- Diseases -- Periodicals; Neck -- Diseases -- Periodicals; Head -- Periodicals; Neck -- Periodicals; Face -- Periodicals; 617.51059
• DOI: 10.1002/hed.25360
• Languages: English
• ISSNs: 1043-3074

Abstract

Abstract: Background: The impact of radiotherapy (RT) modality and dose on survival in hypopharyngeal cancer managed with definitive RT is unclear. Methods: The National Cancer Database was queried for patients with hypopharyngeal squamous cell carcinoma (HPSCC) treated with definitive RT. Intensity‐modulated radiotherapy (IMRT) was compared with other RT techniques. Clinicopathologic variables, RT modality, and dose impact on overall survival (OS) were assessed using log‐rank test and Cox proportional hazard models. Results: A total of 3928 patients with HPSCC were identified. Patients receiving IMRT (2098 patients) were more likely to be white, have higher income, have advanced classification, receive ≥66 Gy, and receive chemoradiotherapy compared with those receiving non‐IMRT techniques (1830 patients). The 5‐year OS was 41.9% (95% CI = 39.4%‐44.4%) for the IMRT group and 36.8% for the non‐IMRT group (95% CI = 34.3%‐39.2%). After propensity score matching, IMRT had significantly better OS ( P = .013). Conclusion: In HPSCC treated with definitive RT, IMRT may provide a significant survival benefit over non‐IMRT modalities.