T-cell leukemogenesis is an inappropriate lineage decision-making process: implications for precision oncology. (4th July 2018)

• Record Type: Journal Article
• Authors: Rodríguez-Hernández, Guillermo; Bhatia, Sanil; Vicente-Dueñas, Carolina; Borkhardt, Arndt; Hauer, Julia; Sánchez-García, Isidro
• Is Part Of: Molecular & cellular oncology. Volume 5:Number 4(2018)
• Publication Date: 2018-07-04
• Subjects: Lmo2 -- Notch1 -- stem cells -- cancer -- mouse models -- target cell -- cancer cell-of-origin -- cancer-stem-cell and tumor reprogramming; Tumors -- Periodicals; Neoplasms; Periodicals; 616.99
• DOI: 10.1080/23723556.2018.1497860
• Languages: English
• ISSNs: 2372-3556

Abstract

ABSTRACT: Genetic lineage tracing in cell type-specific mouse models of T-cell acute lymphoblastic leukemia (T-ALL) have revealed that tumor cell identity is imposed by expression of the oncogene Lim Domain Only 2 ( LMO2), rather than by the target cell phenotype. This approach allowed to identify that secondary genomic alterations, like Notch1 mutations, appeared late and only took place within the thymus during T-ALL development. These concepts are therefore critical for the development of modern therapies aimed at curing T-ALL.