Exiting the dark side: A vital role for Caspase-3 in Yap signaling. (4th July 2018)

• Record Type: Journal Article
• Authors: Yosefzon, Yahav; Fuchs, Yaron
• Is Part Of: Molecular & cellular oncology. Volume 5:Number 4(2018)
• Publication Date: 2018-07-04
• Subjects: Caspase-3 -- Yap -- Catenin -- organ size -- apoptosis; Tumors -- Periodicals; Neoplasms; Periodicals; 616.99
• DOI: 10.1080/23723556.2018.1494947
• Languages: English
• ISSNs: 2372-3556

Abstract

ABSTRACT: Caspase-3 is known to play a critical function in the process of apoptosis. Recently, we have discovered a non-apoptotic role of Caspase-3 as a key regulator of cell proliferation and organ size. Caspase-3 cleaves α-Catenin, which sequesters Yes-associated protein 1 (Yap1) in the cytoplasm, thus facilitating the activation and nuclear translocation of Yap1. These findings reveal that the apoptotic machinery can be refocused to regulate cell proliferation and organ size.