Naphthoquinone rich Onosma visianii Clem (Boraginaceae) root extracts induce apoptosis and cell cycle arrest in HCT-116 and MDA-MB-231 cancer cell lines. Issue 22 (17th November 2018)

• Record Type: Journal Article
• Authors: Vukic, Milena D.; Vukovic, Nenad L.; Obradovic, Ana D.; Popovic, Suzana Lj.; Zaric, Milan M.; Djurdjevic, Predrag M.; Markovic, Snezana D.; Baskic, Dejan D.
• Is Part Of: Natural product research. Volume 32:Issue 22(2018)
• Page Start: 2712
• Page End: 2716
• Publication Date: 2018-11-17
• Subjects: Onosma visianii -- HPLC-PDA analysis -- naphthoquinone extracts -- cytotoxic activity; Natural products -- Periodicals; Natural products -- Research -- Periodicals; Biological Factors -- Periodicals; Biological Products -- Periodicals; 547
• DOI: 10.1080/14786419.2017.1374271
• Languages: English
• ISSNs: 1478-6419

Abstract

Abstract: In the present study, five root extracts of Onosma visianii Clem were investigated for their in vitro cytotoxic activity. On the basis of HPLC-PDA analysis, these extracts have proved to be a rich source of naphthoquinones as natural colourants for food and cosmetic industry. All investigated root extracts contain acetylshikonin, isobutyrylshikonin and α-methylbutyrylshikonin as major compounds. As the most abundant source of active compounds for antitumour therapy, acetone, chloroform and ethyl acetate extracts showed strong cytotoxic activity towards HCT-116 and MDA-MB-231 cancer cell lines. Also, these extracts induced apoptosis and cell cycle arrest in HCT-116 and MDA-MB-231 cancer cell lines. Abstract :