New cerebroside and chondrocyte proliferation activity of Caryota mitis L. Issue 22 (17th November 2018)

• Record Type: Journal Article
• Authors: Trinh, Pham Thi Nhat; Quynh, Nguyen Thi To; Tri, Mai Dinh; Minh, Phan Nhat; Thuy, Nguyen Thi Le; Truong, Luu Hong; Tuan, Nguyen Ngoc; Dung, Le Tien
• Is Part Of: Natural product research. Volume 32:Issue 22(2018)
• Page Start: 2632
• Page End: 2638
• Publication Date: 2018-11-17
• Subjects: Caryoamide -- Caryota mitis -- fruit -- chondrocyte proliferation; Natural products -- Periodicals; Natural products -- Research -- Periodicals; Biological Factors -- Periodicals; Biological Products -- Periodicals; 547
• DOI: 10.1080/14786419.2017.1375919
• Languages: English
• ISSNs: 1478-6419

Abstract

Abstract: Caryota mitis L., a flowering plant, belongs to the family Arecaceae. In Vietnam, its fruits were used to treat joint pain. The present study was designed to investigate the phytochemicals and chondrocyte proliferation activity of C. mitis L. fruits on young human chondrocyte. The results showed that all of extracts (crude extract as well as n-hexane, chloroform, ethyl acetate and methanol fractions) were stimulated the growth of chondrocyte at 0.1 μg/mL; 0.01 μg/mL concentrations, of which the n-hexane and methanol fractions significantly increased the proliferation of chondrocyte by 30.75 and 24.42% at concentrations of 0.01 μg/mL, respectively. Repeated chromatography of the methanol fraction on silica gel, Sephadex LH-20 and ODS columns afforded a new cerebroside and eight known ones. Their structures were elucidated by analysis of spectral data and in comparison with the published reports. Abstract :