LSD1 inhibitors disrupt the GFI1 transcription repressor complex. (4th July 2018) - Maiques-Diaz, Alba
ABSTRACT: Pharmacologic inhibition of KDM1A (Lysine Demethylase 1A) induces differentiation in certain subtypes of acute myeloid leukemia. Our recent studies reveal this is dependent upon drug-induced disruption of the GFI1 (Growth Factor Independent 1) transcription repressor complex, leading to activation of enhancers distributed close to genes controlling monocytic lineage differentiation.