LSD1 inhibitors disrupt the GFI1 transcription repressor complex. (4th July 2018)
- Record Type:
- Journal Article
- Title:
- LSD1 inhibitors disrupt the GFI1 transcription repressor complex. (4th July 2018)
- Main Title:
- LSD1 inhibitors disrupt the GFI1 transcription repressor complex
- Authors:
- Maiques-Diaz, Alba
Lynch, James T.
Spencer, Gary J.
Somervaille, Tim C.P. - Abstract:
- ABSTRACT: Pharmacologic inhibition of KDM1A (Lysine Demethylase 1A) induces differentiation in certain subtypes of acute myeloid leukemia. Our recent studies reveal this is dependent upon drug-induced disruption of the GFI1 (Growth Factor Independent 1) transcription repressor complex, leading to activation of enhancers distributed close to genes controlling monocytic lineage differentiation.
- Is Part Of:
- Molecular & cellular oncology. Volume 5:Number 4(2018)
- Journal:
- Molecular & cellular oncology
- Issue:
- Volume 5:Number 4(2018)
- Issue Display:
- Volume 5, Issue 4 (2018)
- Year:
- 2018
- Volume:
- 5
- Issue:
- 4
- Issue Sort Value:
- 2018-0005-0004-0000
- Page Start:
- Page End:
- Publication Date:
- 2018-07-04
- Subjects:
- GFI1 -- LSD1 -- AML -- epigenetics -- methylation -- acetylation -- leukemia
Tumors -- Periodicals
Neoplasms
Periodicals
616.99 - Journal URLs:
- http://www.tandfonline.com/loi/kmco20#.VyIIeFL2aic ↗
http://www.tandfonline.com/ ↗ - DOI:
- 10.1080/23723556.2018.1481813 ↗
- Languages:
- English
- ISSNs:
- 2372-3556
- Deposit Type:
- Legaldeposit
- View Content:
- Available online (eLD content is only available in our Reading Rooms) ↗
- Physical Locations:
- British Library DSC - BLDSS-3PM
British Library HMNTS - ELD Digital store - Ingest File:
- 9286.xml