Long noncoding RNA Malat1 is not essential for T cell development and response to LCMV infection. Issue 12 (2nd December 2018)

• Record Type: Journal Article
• Authors: Yao, Yingpeng; Guo, Wenhui; Chen, Jingjing; Guo, Pingting; Yu, Guotao; Liu, Juanjuan; Wang, Fang; Liu, Jingjing; You, Menghao; Zhao, Tianyan; Kang, Youmin; Ma, Xi; Yu, Shuyang
• Is Part Of: RNA biology. Volume 15:Issue 12(2018)
• Page Start: 1477
• Page End: 1486
• Publication Date: 2018-12-02
• Subjects: lncRNA -- Malat1 -- T cell development -- effector CD8+ T cells -- memory CD8+ T cells -- TFH cells; RNA -- Periodicals; Molecular biology -- Periodicals; Molecular biology; RNA; Periodicals; 572.8805
• DOI: 10.1080/15476286.2018.1551705
• Languages: English
• ISSNs: 1547-6286

Abstract

ABSTRACT: Long noncoding RNAs (lncRNAs) are emerging as critical mediators of various biological processes in the immune system. The current data showed that the lncRNA Malat1 is highly expressed in T cell subsets, but the function of Malat1 in T cell remains unclear. In this study, we detected the T cell development and both CD8 + and CD4 + T cell response to LCMV infection using Malat1 −/- mice model. To our surprise, there were no significant defects in thymocytes at different developmental stages and the peripheral T cell pool with ablation of Malat1. During LCMV infection, Malat1 −/- mice exhibited normal effector and memory CD8 + T cells as well as TFH cells differentiation. Our results indicated that Malat1 is not essential for T cell development and T cell-mediated antiviral response though it expresses at very high level in different T cell populations.