Macropinocytosis and autophagy crosstalk in nutrient scavenging. (17th December 2018)

• Record Type: Journal Article
• Authors: Florey, Oliver; Overholtzer, Michael
• Is Part Of: Philosophical transactions. Volume 374:Number 1765(2019)
• Publication Date: 2018-12-17
• Subjects: macropinocytosis -- autophagy -- entosis, phagocytosis; Biology -- Periodicals; Science -- Periodicals; 570
• DOI: 10.1098/rstb.2018.0154
• Languages: English
• ISSNs: 0962-8436

Abstract

Abstract : Adaptive strategies used by cells to scavenge and recycle essential nutrients are important for survival in nutrient-depleted environments such as cancer tissues. Autophagy and macropinocytosis are two major mechanisms that promote nutrient recycling and scavenging, which share considerable, yet poorly understood, cross-regulation. Here we review recent findings that connect these starvation response mechanisms and discuss the implications of their crosstalk. This article is part of the Theo Murphy meeting issue 'Macropinocytosis'.