A divergent method to key unit of tubulysin V through one-pot diastereoselective Mannich process of N, O-acetal with ketone. Issue 2 (11th January 2019)
- Record Type:
- Journal Article
- Title:
- A divergent method to key unit of tubulysin V through one-pot diastereoselective Mannich process of N, O-acetal with ketone. Issue 2 (11th January 2019)
- Main Title:
- A divergent method to key unit of tubulysin V through one-pot diastereoselective Mannich process of N, O-acetal with ketone
- Authors:
- Wang, Xue-Mei
Liu, Yi-Wen
Wang, Qiao-E
Zhou, Zhu
Si, Chang-Mei
Wei, Bang-Guo - Abstract:
- Abstract: An efficient diastereoselective approach to access ( 4R )-hydroxy-( 2S )-substituted methyl ketones pyrroles skeleton4a-s has been developed through Mannich process involving N, O -acetal6 and ketones and propionaldehyde in excellent yield with high diastereoselectivity ( dr up to 99:1). In addition, the utility of this convenient Mannich process is demonstrated by the diastereoselective synthesis of Tuv fragment (2 ) and its analogue (18 ) of tubulysin V(1e) . Graphical abstract:
- Is Part Of:
- Tetrahedron. Volume 75:Issue 2(2019)
- Journal:
- Tetrahedron
- Issue:
- Volume 75:Issue 2(2019)
- Issue Display:
- Volume 75, Issue 2 (2019)
- Year:
- 2019
- Volume:
- 75
- Issue:
- 2
- Issue Sort Value:
- 2019-0075-0002-0000
- Page Start:
- 260
- Page End:
- 268
- Publication Date:
- 2019-01-11
- Subjects:
- Asymmetric synthesis -- Natural product -- Mannich reaction -- N, O-acetal -- Tubulysins
Chemistry, Organic -- Periodicals
547.005 - Journal URLs:
- http://www.elsevier.com/journals ↗
- DOI:
- 10.1016/j.tet.2018.11.053 ↗
- Languages:
- English
- ISSNs:
- 0040-4020
- Deposit Type:
- Legaldeposit
- View Content:
- Available online (eLD content is only available in our Reading Rooms) ↗
- Physical Locations:
- British Library DSC - 8796.850000
British Library DSC - BLDSS-3PM
British Library STI - ELD Digital store - Ingest File:
- 9272.xml