Triskelion channels might bring Star Wars to the global problem of hypertension. (January 2019) - Beech, David J.
Graphical abstract: Highlights: The new report by Zeng et al ( Science 2018) suggests that neuronal Piezo1 and Piezo2 channels sense blood pressure in major arteries above the heart. The data challenge previous proposed baroreceptor mechanisms. The data add to prior knowledge of Piezo1 channels as sensors of blood flow and key players generally in cardiovascular biology. Abstract: In a compelling new report Zeng et al. ( Science 2018) suggest that neuronal Piezo1 and Piezo2 channels sense blood pressure in major arteries above the heart [1 ]. The data challenge previous proposed baroreceptor mechanisms and add to prior knowledge of Piezo1 channels as sensors of blood flow and key players generally in cardiovascular biology.