Diversity of Quaternary Structures Regulates Nuclear Receptor Activities. Issue 1 (January 2019)

• Record Type: Journal Article
• Authors: Fuentes-Prior, Pablo; Rojas, Ana; Hagler, Arnold T.; Estébanez-Perpiñá, Eva
• Is Part Of: Trends in biochemical sciences. Volume 44:Issue 1(2019)
• Page Start: 2
• Page End: 6
• Publication Date: 2019-01
• Subjects: Nuclear receptors -- quaternary structure -- protein–protein interaction surfaces -- structure–function -- monomer-oligomer transition; Biochemistry -- Periodicals; 572
• DOI: 10.1016/j.tibs.2018.09.005
• Languages: English
• ISSNs: 0968-0004

Abstract

Abstract : Nuclear receptors (NRs) form homo- and/or heterodimers as central scaffolds of multiprotein complexes, which activate or repress gene transcription to regulate development, homeostasis, and metabolism. Recent studies on NR quaternary structure reveal novel mechanisms of receptor dimerization, the existence of tetrameric chromatin-bound NRs, and previously unanticipated protein–protein/protein–DNA interactions.