EGR-mediated control of STIM expression and function. (January 2019)

• Record Type: Journal Article
• Authors: Go, Christina K.; Gross, Scott; Hooper, Robert; Soboloff, Jonathan
• Is Part Of: Cell calcium. Volume 77(2019)
• Page Start: 58
• Page End: 67
• Publication Date: 2019-01
• Subjects: Early growth response factors -- STIM1 -- PMCA -- Store-operated calcium entry -- Calcium signaling; Calcium -- Metabolism -- Periodicals; Vertebrates -- Physiology -- Periodicals; Calcium -- Physiological effect -- Periodicals; Cell physiology -- Periodicals; Calcium in the body -- Periodicals; 572.516
• DOI: 10.1016/j.ceca.2018.12.003
• Languages: English
• ISSNs: 0143-4160

Abstract

Graphical abstract: Highlights: EGR/WT1 factors can bind to the same sites, where their transcriptional activity is controlled by epigenetic marks and binding partners. EGR/WT1 factors control the expression of multiple Ca 2+ homeostasis genes including STIM1, STIM2, PMCA4 and SERCA. EGR/WT1-mediated changes in Ca 2+ homeostasis controls inflammation, leading to cardiovascular pathologies. EGR/WT1-mediated changes in Ca 2+ homeostasis can contribute to tumor formation and progression through crosstalk with multiple pathways. Abstract: Ca 2+ is a ubiquitous, dynamic and pluripotent second messenger with highly context-dependent roles in complex cellular processes such as differentiation, proliferation, and cell death. These Ca 2+ signals are generated by Ca 2+ -permeable channels located on the plasma membrane (PM) and endoplasmic reticulum (ER) and shaped by PM- and ER-localized pumps and transporters. Differences in the expression of these Ca 2+ homeostasis proteins contribute to cell and context-dependent differences in the spatiotemporal organization of Ca 2+ signals and, ultimately, cell fate. This review focuses on the Early Growth Response (EGR) family of zinc finger transcription factors and their role in the transcriptional regulation of Stromal Interaction Molecule (STIM1), a critical regulator of Ca 2+ entry in both excitable and non-excitable cells.