Intraventricular blood flow with a fully dynamic mitral valve model. (January 2019)

• Record Type: Journal Article
• Authors: Khalafvand, Seyed Saeid; Xu, Fei; Westenberg, Jos; Gijsen, Frank; Kenjeres, Sasa
• Is Part Of: Computers in biology and medicine. Volume 104(2019)
• Page Start: 197
• Page End: 204
• Publication Date: 2019-01
• Subjects: Blood flow -- Mitral valve -- Left ventricle -- Boundary value problem -- Vortices -- Dynamic mesh -- CFD; Medicine -- Data processing -- Periodicals; Biology -- Data processing -- Periodicals; 610.285
• DOI: 10.1016/j.compbiomed.2018.11.024
• Languages: English
• ISSNs: 0010-4825

Abstract

Abstract: Mitral valve (MV) leaflets affect the formation, growth, and decay of vortices in the left ventricle (LV) during diastolic filling. The shape and motion of MV leaflets are simplified in most studies due to computational restrictions. In this study, we present a newly developed mathematical method to model the dynamic movement of valve leaflets and annulus, which is based on in vivo data obtained with magnetic resonance imaging (MRI). In the present method, we solve a boundary value problem where the MV surface is initially unknown. The resultant MV shapes are included in a dynamic motion model of the LV to assess the change of intraventricular flow patterns. To estimate the effects of the MV on left intraventricular flow, a LV model without MV leaflets was also simulated for comparison. Our study showed that the presence of the MV and the shape of its leaflets significantly altered the formation and evolution of vortex structures in the LV. The various MV leaflet shapes accelerate the transvalvular flow distinctly, leading to different formation and development of vortex structures. Graphical abstract: Highlights: A mathematical model of fully dynamic MV leaflets motion coupling with LV motion. A surface grid generation code based on opening angles and MV boundaries from MRI. Including upward/downward and contraction/dilation of MV annulus. The method working based on inputs from images (MRI, TOE or other imaging methods). Performed a comparison between different shapes of MV and their effects on LV flow.