Regulation of thermoTRPs by lipids. Issue 1 (31st March 2017)

• Record Type: Journal Article
• Authors: Morales-Lázaro, Sara L.; Lemus, Luis; Rosenbaum, Tamara
• Is Part Of: Temperature. Volume 4:Issue 1(2017)
• Page Start: 24
• Page End: 40
• Publication Date: 2017-03-31
• Subjects: cholesterol -- lysophosphatidic acid -- lysophosphatidylcholine -- monounsaturated fatty acids -- oleic acid -- PIP2 -- TRP channels -- thermoTRP; Thermobiology -- Periodicals; Thermotherapy -- Periodicals; Body temperature -- Regulation -- Periodicals; Body temperature -- Regulation; Thermobiology; Thermotherapy; Periodicals; 571.46
• DOI: 10.1080/23328940.2016.1254136
• Languages: English
• ISSNs: 2332-8940

Abstract

ABSTRACT: The family of Transient Receptor Potential (TRP) ion channels is constituted by 7 subfamilies among which are those that respond to temperature, the thermoTRPs. These channels are versatile molecules of a polymodal nature that have been shown to be modulated in various fashions by molecules of a lipidic nature. Some of these molecules interact directly with the channels on specific regions of their structures and some of these promote changes in membrane fluidity or modify their gating properties in response to their agonists. Here, we have discussed how some of these lipids regulate the activity of thermoTRPs and included some of the available evidence for the molecular mechanisms underlying their effects on these channels.