Model answers: Rational application of murine models in arthritis research. Issue 1 (14th December 2017)

• Record Type: Journal Article
• Authors: Benson, Robert A.; McInnes, Iain B.; Garside, Paul; Brewer, James M.
• Is Part Of: European journal of immunology. Volume 48:Issue 1(2018)
• Page Start: 32
• Page End: 38
• Publication Date: 2017-12-14
• Subjects: Animal model -- Autoimmunity -- Experimental arthritis -- Rheumatology -- Therapy; Immunology -- Periodicals; 616.079
• DOI: 10.1002/eji.201746938
• Languages: English
• ISSNs: 0014-2980

Abstract

Abstract: Advances in targeted immune therapeutics have profoundly improved clinical outcomes for patients with inflammatory arthropathies particularly rheumatoid arthritis. The landscape of disease that is observed and the treatment outcomes desired for the future have also progressed. As such there is an increasing move away from traditional models of end‐stage, chronic disease with recognition of the need to consider the earliest phases of pathogenesis as a target for treatment leading to resolution and/or cure. In order to continue the discovery process and enhance our understanding of disease and treatment, we therefore need to continuously revisit the animal models we employ and assess their relevance and utility in the light of contemporary therapeutic goals. In this review, we highlight the areas where we consider new developments in animal models and their application are most required. Thus, we have contextualised the relevant mouse models and their use within the current concepts of human inflammatory arthritis pathogenesis and highlight areas of need. Abstract : Murine models represent powerful tools in testing important biological concepts in rheumatoid arthritis (RA). We highlight areas of new developments in animal models and highlight areas of unmet need. In doing so, we contextualise relevant mouse models and their use within the current pathogenesis concepts of human autoimmune inflammatory arthritis.