MR imaging of hepatocellular adenomas on genotype-phenotype classification: A report from China. Issue 100 (March 2018)

• Record Type: Journal Article
• Authors: Wang, Heqing; Yang, Chun; Rao, Shengxiang; Ji, Yuan; Han, Jing; Sheng, Ruofan; Zeng, Mengsu
• Is Part Of: European journal of radiology. Issue 100(2018)
• Page Start: 135
• Page End: 141
• Publication Date: 2018-03
• Subjects: HCA hepatocellular adenoma -- I-HCA inflammatory HC -- H-HCA hepatocyte nuclear factor 1 alpha-mutated HCA -- B-HCA β-catenin-mutated HCA -- U-HCA unclassified HCA -- DWI diffusion-weighted imaging -- BMI body-mass index -- PACS picture archiving and communication system -- SI signal intensity -- T1WI T1-weighted imaging -- T2WI T2-weighted imaging -- ADC apparent diffusion coefficient -- ROI region of interest -- LFABP liver fatty acid binding protein -- SAA serum amyloid A -- GS glutathione synthetase -- HBV hepatitis B virus -- HCC hepatocellular carcinoma; Hepatocellular adenoma -- Magnetic resonance imaging -- Liver; Medical radiology -- Periodicals; Radiology -- Periodicals; Radiologie médicale -- Périodiques; Medical radiology; Periodicals; 616.075705
• DOI: 10.1016/j.ejrad.2018.01.023
• Languages: English
• ISSNs: 0720-048X

Abstract

Highlights: A good relationship exists between MR features and HCA subtype classification. Both clinical and MR features of HCA in China have some specific characteristics. ADC value may provide a potential indicator of malignant transformation. Abstract: Purpose: To investigate and compare the MR features between hepatocellular adenoma (HCA) subtypes in China, including preliminary observations on diffusion-weighted imaging (DWI). Methods: Thirty-six patients with 39 pathologically proven HCAs underwent gadopentetate dimeglumine enhanced MRI. The morphological and imaging features on T1, T2-weighted, dynamic-enhanced imaging and DWI were retrospectively evaluated and compared between four HCA subtypes, using Kruskal-Wallis test, Fisher's exact test and Dunn-Bonferroni post hoc test. Results: HCA frequently occurred in male (n = 19, 52.8%), lacked an association with oral contraceptives (n = 0), and had a relatively high incidence of coexistent Hepatitis B infection (n = 6, 16.7%). Signals on T1 and T2-weighted imaging, enhancement pattern and intensity, lesion heterogeneity, as well as accompanying findings including lesion steatosis, necrosis or cystic component, central scar, and pseudocapsule were different between HCA subtypes ( P < .0001 to P = .019). Apparent diffusion coefficient (ADC) values among HCA subtypes were different as a whole ( P = .029), within which β-catenin-mutated HCA had the lowest ADCs; but post hoc comparisons demonstrated no significant differences between groups ( P = .066–1.000). Conclusion: Both clinical and MR imaging presentation of HCA in China had some specific characteristics, and a good relationship existed between MR data and genotype-phenotype classification. Furthermore, ADC value may provide a potential indicator of malignant transformation.