A BODIPY-based dual-responsive turn-on fluorescent probe for NO and nitrite. (August 2018)
- Record Type:
- Journal Article
- Title:
- A BODIPY-based dual-responsive turn-on fluorescent probe for NO and nitrite. (August 2018)
- Main Title:
- A BODIPY-based dual-responsive turn-on fluorescent probe for NO and nitrite
- Authors:
- Zhang, Jian
Pan, Fuchao
Jin, Yue
Wang, Nannan
He, Jinling
Zhang, Weijuan
Zhao, Weili - Abstract:
- Abstract: O -phenylenediamine-BODIPY-based dual-responsive turn-on low-background fluorescence probe1 for the detection both NO and nitrite has been successfully designed through attachment of a BODIPY dye at the meso position with the amino group of o -phenylenediamine. Probe1 is intrinsically none fluorescent due to PET effect, however it turns quickly into highly fluorescent state upon treatment with NO in neutral condition or nitrite in acidic environment with high selectivity and low detection limit. The resulted 8-benzotriazolyl BODIPY dye could recognize biothiol such as Cys, Hcy, and GSH. In the cell imaging experiments, only blue fluorescence could be observed with probe1 using DEA·NONOate as the source of NO and assisted by intracellular Cys and GSH. Our results may inspire and encourage researchers to use such a convenient tool for studying the effects of NO and nitrite in biological and pharmacological studies. Graphical abstract: A o -phenylenediamine-BODIPY-based dual-response turn-on low-background fluorescence probe1 for sensitive and selective detection of NO and nitrite has been successfully developed. The resulted 8-benzotriazolyl BODIPY could recognize bithiol such as Cys, Hcy, and GSH. Highlights: A o -phenylenediamine-BODIPY-based dual-responsive turn-on low-background fluorescence probe for NO and nitrite was developed. The probe could detect NO or nitrite with high selectivity and low detection limit. The resulted 8-benzotriazolyl BODIPY dye couldAbstract: O -phenylenediamine-BODIPY-based dual-responsive turn-on low-background fluorescence probe1 for the detection both NO and nitrite has been successfully designed through attachment of a BODIPY dye at the meso position with the amino group of o -phenylenediamine. Probe1 is intrinsically none fluorescent due to PET effect, however it turns quickly into highly fluorescent state upon treatment with NO in neutral condition or nitrite in acidic environment with high selectivity and low detection limit. The resulted 8-benzotriazolyl BODIPY dye could recognize biothiol such as Cys, Hcy, and GSH. In the cell imaging experiments, only blue fluorescence could be observed with probe1 using DEA·NONOate as the source of NO and assisted by intracellular Cys and GSH. Our results may inspire and encourage researchers to use such a convenient tool for studying the effects of NO and nitrite in biological and pharmacological studies. Graphical abstract: A o -phenylenediamine-BODIPY-based dual-response turn-on low-background fluorescence probe1 for sensitive and selective detection of NO and nitrite has been successfully developed. The resulted 8-benzotriazolyl BODIPY could recognize bithiol such as Cys, Hcy, and GSH. Highlights: A o -phenylenediamine-BODIPY-based dual-responsive turn-on low-background fluorescence probe for NO and nitrite was developed. The probe could detect NO or nitrite with high selectivity and low detection limit. The resulted 8-benzotriazolyl BODIPY dye could recognize biothiols such as Cys, Hcy, and GSH. … (more)
- Is Part Of:
- Dyes and pigments. Volume 155(2018)
- Journal:
- Dyes and pigments
- Issue:
- Volume 155(2018)
- Issue Display:
- Volume 155, Issue 2018 (2018)
- Year:
- 2018
- Volume:
- 155
- Issue:
- 2018
- Issue Sort Value:
- 2018-0155-2018-0000
- Page Start:
- 276
- Page End:
- 283
- Publication Date:
- 2018-08
- Subjects:
- Dual-responsive -- Fluorescent probe -- NO -- Nitrite -- Biothiol
Dyes and dyeing -- Periodicals
Pigments -- Periodicals
667.2 - Journal URLs:
- http://www.sciencedirect.com/science/journal/01437208 ↗
http://www.elsevier.com/journals ↗ - DOI:
- 10.1016/j.dyepig.2018.03.035 ↗
- Languages:
- English
- ISSNs:
- 0143-7208
- Deposit Type:
- Legaldeposit
- View Content:
- Available online (eLD content is only available in our Reading Rooms) ↗
- Physical Locations:
- British Library DSC - 3635.600000
British Library DSC - BLDSS-3PM
British Library HMNTS - ELD Digital store - Ingest File:
- 9246.xml