A BODIPY-based dual-responsive turn-on fluorescent probe for NO and nitrite. (August 2018)

• Record Type: Journal Article
• Authors: Zhang, Jian; Pan, Fuchao; Jin, Yue; Wang, Nannan; He, Jinling; Zhang, Weijuan; Zhao, Weili
• Is Part Of: Dyes and pigments. Volume 155(2018)
• Page Start: 276
• Page End: 283
• Publication Date: 2018-08
• Subjects: Dual-responsive -- Fluorescent probe -- NO -- Nitrite -- Biothiol; Dyes and dyeing -- Periodicals; Pigments -- Periodicals; 667.2
• DOI: 10.1016/j.dyepig.2018.03.035
• Languages: English
• ISSNs: 0143-7208

Abstract

Abstract: O -phenylenediamine-BODIPY-based dual-responsive turn-on low-background fluorescence probe1 for the detection both NO and nitrite has been successfully designed through attachment of a BODIPY dye at the meso position with the amino group of o -phenylenediamine. Probe1 is intrinsically none fluorescent due to PET effect, however it turns quickly into highly fluorescent state upon treatment with NO in neutral condition or nitrite in acidic environment with high selectivity and low detection limit. The resulted 8-benzotriazolyl BODIPY dye could recognize biothiol such as Cys, Hcy, and GSH. In the cell imaging experiments, only blue fluorescence could be observed with probe1 using DEA·NONOate as the source of NO and assisted by intracellular Cys and GSH. Our results may inspire and encourage researchers to use such a convenient tool for studying the effects of NO and nitrite in biological and pharmacological studies. Graphical abstract: A o -phenylenediamine-BODIPY-based dual-response turn-on low-background fluorescence probe1 for sensitive and selective detection of NO and nitrite has been successfully developed. The resulted 8-benzotriazolyl BODIPY could recognize bithiol such as Cys, Hcy, and GSH. Highlights: A o -phenylenediamine-BODIPY-based dual-responsive turn-on low-background fluorescence probe for NO and nitrite was developed. The probe could detect NO or nitrite with high selectivity and low detection limit. The resulted 8-benzotriazolyl BODIPY dye could recognize biothiols such as Cys, Hcy, and GSH.