Altered functional connectivity in post-ischemic stroke depression: A resting-state functional magnetic resonance imaging study. Issue 100 (March 2018)

• Record Type: Journal Article
• Authors: Zhang, Peiyao; Wang, Jing; Xu, Qin; Song, Zheng; Dai, Jianping; Wang, Jun
• Is Part Of: European journal of radiology. Issue 100(2018)
• Page Start: 156
• Page End: 165
• Publication Date: 2018-03
• Subjects: PSD post stroke depression -- FC functional connectivity -- DMN default mood network -- CCN cognitive control network -- AN affective network -- HDRS Hamilton Depression Rating Scale -- NC normal controls -- rs-fMRI resting-state functional magnetic resonance imaging -- ACC anterior cingulate cortex -- DSM-IV, fourth edition Diagnostic and Statistical Manual of Mental Disorders -- MRI magnetic resonance image -- MP-RAGE magnetization-prepared rapid gradient echo -- PCC posterior cingulate cortices -- DLPFC dorsolateral prefrontal cortices -- ROIs regions of interest -- ANOVA one-way analysis of variance -- BG basal ganglia -- CR coronal radiation -- F frontal lobe -- P parietal lobe -- O occipital lobe -- B bilateral -- R right -- L left -- ITG inferior temporal gyrus -- PUT putamen -- IPL inferior parietal gyrus -- PCUN precuneus -- MTG middle temporal gyrus -- SFGdor superior frontal gyrus, dorsolateral -- MFG middle frontal gyrus -- SFGmed superior frontal gyrus medial -- TPOsup superior temporal gyrus -- BA Broadman area -- MNI Montreal Neurological Institute spatial array coordinates -- ORBinf inferior frontal gyrus, orbital part -- IFGtriang inferior frontal gyrus, triangular part -- ORBsup superior frontal gyrus, orbital part -- STG superior temporal gyrus -- ANG angular gyrus -- SFG superior frontal gyrus -- MDD major depressive disorder -- Cohe-ReHo coherence-based regional homogeneity; Resting state fMRI -- PSD -- Functional connectivity -- Functional networks; Medical radiology -- Periodicals; Radiology -- Periodicals; Radiologie médicale -- Périodiques; Medical radiology; Periodicals; 616.075705
• DOI: 10.1016/j.ejrad.2018.01.003
• Languages: English
• ISSNs: 0720-048X

Abstract

Abstract: Objective: In previous studies, post-stroke depression (PSD) was found to be related to stroke characteristics as well as social and psychological factors. This study identified altered functional connectivity (FC) in patients with PSD at the subacute phase in three brain networks: default mood network (DMN), cognitive control network (CCN), and affective network (AN). The correlation between FC and the severity of PSD was investigated. Materials and methods: Resting-state functional magnetic resonance image (rs-fMRI) was performed on 26 PSD patients (6 females), 24 stroke patients without depression (5 females), and 24 age-matched normal controls (6 females) all aged 40–75 years. The FC values of DMN, CCN, and AN were calculated and compared among the three groups. The Hamilton Depression Rating Scale (HDRS) (17 items) was employed and the score was correlated with FC in the PSD group. Results: The FCs of the three networks were altered in PSD patients at the subacute phase compared to stroke patients without depression and normal controls (NC). Moreover, the left inferior parietal gyrus, the left orbital part of inferior frontal gyrus, and left angular gyrus (which indicated altered FC) were significantly correlated with HDRS scores in PSD patients. Conclusions: Alteration of the three neural networks might be correlated with the development of PSD at the subacute phase of stroke.