Harnessing open-source technology for low-cost automation in synthesis: Flow chemical deprotection of silyl ethers using a homemade autosampling system. Issue 25 (21st June 2017)

• Record Type: Journal Article
• Authors: O'Brien, Matthew; Konings, Lisette; Martin, Matthew; Heap, Jordan
• Is Part Of: Tetrahedron letters. Volume 58:Issue 25(2017)
• Page Start: 2409
• Page End: 2413
• Publication Date: 2017-06-21
• Subjects: Open-source -- Automation -- Flow chemistry -- Desilylation -- Liquid-liquid extraction; Chemistry, Organic -- Periodicals; 547.005
• DOI: 10.1016/j.tetlet.2017.05.008
• Languages: English
• ISSNs: 0040-4039

Abstract

Graphical abstract: Highlights: A home-made 3-axis autosampler was used to provide low-cost automation in a series of flow chemical desilylation reactions. System control was achieved using a number of open-source software components (Python, OpenCV, PySerial). A Raspberry Pi single-board-computer was used to provide an interface to the electronic hardware components. Abstract: An inexpensive homemade 3-axis autosampler was used to facilitate the automation of an acid catalysed flow chemical desilylation reaction. Harnessing open-source software technologies (Python, OpenCV), an automated computer-vision controlled liquid-liquid extraction step was used to provide effective inline purification. A Raspberry Pi single-board computer was employed to interface with the motors used in the autosampler and actuated fluidic valves.