How much is enough—Can resting state fMRI provide a demarcation for neurosurgical resection in glioma?. (January 2018)

• Record Type: Journal Article
• Authors: Ghinda, Diana C.; Wu, Jin-Song; Duncan, Niall W.; Northoff, Georg
• Is Part Of: Neuroscience and biobehavioral reviews. Volume 84(2018)
• Page Start: 245
• Page End: 261
• Publication Date: 2018-01
• Subjects: BOLD blood oxygen level-dependent -- ICA independent component analysis -- ROI region of interest -- rs-fMRI resting-state functional magnetic resonance imaging -- tb-fMRI task-based functional magnetic resonance imaging -- RSN resting-state network -- RSC resting state connectivity -- LN language network -- NVU neurovascular uncoupling -- ICA independent component analysis -- ReHo regional homogeneity -- ALFF amplitude of low-frequency fluctuation -- fALFF fractional ALFF -- CSM cortical stimulation mapping -- LGG low-grade glioma -- DLGG diffuse LGG -- HGG high-grade glioma -- HC healthy control -- FC functional connectivity -- DMN default mode network -- PMC premotor cortex -- PCC posterior cingulate cortex; Glioma -- Glioblastoma -- Diffuse low grade glioma -- Brain tumors -- Resting-state -- Functional connectivity -- Sensorimotor network -- Language network -- Default mode network -- Neuroplasticity; Psychophysiology -- Periodicals; Human behavior -- Periodicals; Animal behavior -- Periodicals; Neurology -- Periodicals; Behavior -- Periodicals; Ethology -- Periodicals; Neurology -- Periodicals; Psychophysiologie -- Périodiques; Comportement humain -- Périodiques; Animaux -- Mœurs et comportement -- Périodiques; Neurologie -- Périodiques; Animal behavior; Human behavior; Neurology; Psychophysiology; Periodicals; Electronic journals; 573.8
• DOI: 10.1016/j.neubiorev.2017.11.019
• Languages: English
• ISSNs: 0149-7634

Abstract

Highlights: Rs-fMRI is a suitable alternative to task-based fMRI in patients who are unable to cooperate. There is considerable evidence of diffuse functional reorganization occurring in the setting of gliomas. There are local and interhemispheric functional connectivity alterations involving different networks. Rs-fMRI may yield new functional biomarkers of glioma that could improve the ability to diagnose, treat and predict patients' outcomes. Abstract: This study represents a systematic review of the insights provided by resting state functional MRI (rs-fMRI) use in the glioma population. Following PRISMA guidelines, 45 studies were included in the review and were classified in glioma-related neuronal changes (n = 28) and eloquent area localization (n = 17). Despite the heterogeneous nature of the studies, there is considerable evidence of diffuse functional reorganization occurring in the setting of gliomas with local and interhemispheric functional connectivity alterations involving different functional networks. The studies showed evidence of decreased long distance functional connectivity and increased global local efficiency occurring in the setting of gliomas. The tumour grade seems to correlate with distinct functional connectivity changes. Overall, there is a potential clinical utility of rs-fMRI for identifying the functional brain network disruptions occurring in the setting of gliomas. Further studies utilizing standardized analytical methods are required to elucidate the mechanism through which gliomas induce global changes in brain connectivity.