Obesity: Lifestyle management, bariatric surgery, drugs, and the therapeutic exploitation of gut hormones. Issue 5 (August 2015)

• Record Type: Journal Article
• Authors: Behary, Preeshila; Cegla, Jaimini; Tan, Tricia M.; Bloom, Stephen R.
• Is Part Of: Postgraduate medicine. Volume 127:Issue 5(2015)
• Page Start: 494
• Page End: 502
• Publication Date: 2015-08
• Subjects: Obesity -- lifestyle management -- bariatric surgery -- drugs -- gut hormones; Medicine -- Periodicals; Medicine -- Periodicals; Medicine; Periodicals; 610.5
• DOI: 10.1080/00325481.2015.1048181
• Languages: English
• ISSNs: 0032-5481

Abstract

Abstract: Obesity is on the rise and the pursuit of efficient and safe treatment is ongoing. Available anti-obesity medical therapies have so far proved to be disappointing, whereas bariatric surgery is leading the way and offers long-term health benefits. Part of the success of bariatric surgery is thought to be mediated by gut hormones. A better understanding of the role of gut hormones within the gut-brain signaling pathway in the control of hunger, satiety, and energy homeostasis, has led to their therapeutic exploitation as possible anti-obesity drugs. In this review, we provide a summary of currently available treatment options for obesity from simple lifestyle modifications and bariatric surgery to traditional and novel medical therapies.