Comparison of an interferon-gamma release assay and the tuberculin skin test for diagnosis of latent tuberculosis in homeless people in Iran: a cross-sectional study. Issue 8 (August 2015)

• Record Type: Journal Article
• Authors: Bagheri Amiri, Fahimeh; Saifi, Mahnaz; Gouya, Mohammad Mehdi; Rohani, Mahdi; Mostafavi, Ehasn
• Is Part Of: Infectious diseases. Volume 47:Issue 8(2015:Aug.)
• Page Start: 536
• Page End: 541
• Publication Date: 2015-08
• Subjects: Latent tuberculosis -- tuberculin skin test -- QuantiFERON -- homeless -- concordance; Communicable diseases -- Periodicals; Communicable Diseases -- Periodicals; Communicable diseases; Periodicals; 616.9
• DOI: 10.3109/23744235.2015.1026934
• Languages: English
• ISSNs: 2374-4235

Abstract

Abstract: Background: The aim of this study was to evaluate of the concordance between the results of the tuberculin skin test (TST) and an interferon-γ release assay (QuantiFERON test, QFT-GIT) for diagnosis of latent tuberculosis infection (LTBI) in homeless people in Tehran city, Iran. Methods: This cross-sectional study was conducted from June to August 2012. Homeless people were eligible to participate in the study if they were 18–60 years old. Results: Among 569 homeless people, 46.22% (95% confidence interval (CI) = 42.16–50.33%) and 20.39% (95% CI = 17.28–23.9%) were QFT-GIT and TST positive, respectively. Among these participants, the prevalence of LTBI with positivity of at least one of the tests was 52.2%. The overall agreement between QFT-GIT and TST was 62.21% (kappa = 0.21, 95% CI = 0.13–0.29, p < 0.001). Factors associated with positive results in QFT-GIT and TST were older age, being male, having a longer history of homelessness and having a history of incarceration in the last 10 years. Conclusions: A high prevalence of LTBI was seen among homeless people in this study. There was a poor concordance between QFT-GIT and TST among this group. To better assess the utility of QFT-GIT in detection of LTBI further studies with a low prevalence of LTBI in this group are recommended.