1, 5‐Diketones Synthesis via Three‐Component Cascade Reaction. Issue 14 (13th October 2015)

• Record Type: Journal Article
• Authors: Xing, Li‐Juan; Lu, Tao; Fu, Wei‐Li; Lou, Mei‐Mei; Chen, Bo; Wang, Zhi‐Shen; Jin, Yang; Li, Dan; Wang, Bin
• Is Part Of: Advanced synthesis & catalysis. Volume 357:Issue 14/15(2015)
• Page Start: 3076
• Page End: 3080
• Publication Date: 2015-10-13
• Subjects: cascade reaction -- 1, 5‐diketones -- metal‐free conditions -- N‐methylamine -- trifluoroacetate release; Catalysis -- Periodicals; Organic compounds -- Synthesis -- Periodicals; Chemistry -- Periodicals; Chemistry, Technical -- Periodicals; Chemistry -- Periodicals; Catalysis -- Periodicals; Technology, Pharmaceutical -- Periodicals; 547.2
• DOI: 10.1002/adsc.201500691
• Languages: English
• ISSNs: 1615-4150

Abstract

Abstract: A mild and efficient cascade synthesis of 1, 5‐diketones from readily available N, N ‐dicyclohexylmethylamine, 1, 3‐dicarbonyl compounds, and trifluoromethyl β‐diketones has been developed. This cascade reaction occurs via an oxidation/Mannich reaction/Cope elimination/Michael addition/retro‐Claisen reaction sequence, and provides multiple CC bond formations in one pot. In addition, exquisite chemoselectivity is achieved in the reaction between 1, 3‐dicarbonyl compounds and trifluoromethyl β‐diketones. Abstract :