Comparative In Vitro Study of Different Atmospheric Pressure Plasma Jets Concerning their Antimicrobial Potential and Cellular Reaction. Issue 10 (23rd March 2015)

• Record Type: Journal Article
• Authors: Duske, Kathrin; Wegner, Katharina; Donnert, Monique; Kunert, Ulrike; Podbielski, Andreas; Kreikemeyer, Bernd; Gerling, Torsten; Weltmann, Klaus‐Dieter; Nebe, Barbara; Bader, Rainer
• Is Part Of: Plasma processes and polymers. Volume 12:Issue 10(2015:Oct.)
• Page Start: 1050
• Page End: 1060
• Publication Date: 2015-03-23
• Subjects: biofilm -- cell adhesion -- implant surface -- osteoblasts -- plasma jet; Plasma polymerization -- Periodicals; Plasma-enhanced chemical vapor deposition -- Periodicals; Plasma chemistry -- Periodicals
• DOI: 10.1002/ppap.201400176
• Languages: English
• ISSNs: 1612-8850

Abstract

Abstract : Atmospheric pressure plasma‐jets could be an alternative method to remove bacterial biofilms on orthopaedic implants. Furthermore, plasma‐exposure might support the proliferation of osteoblasts after cleaning implants by activating the implant surface. In this comparative in vitro study, the efficacy of five different plasma sources concerning removal of bacterial biofilms and influence on human osteoblast cell attachment was tested. Two plasma sources revealed a significant reduction of bacterial viability (>90%) and enhanced spreading of osteoblastic cells. Promising results and potential for local plasma‐jet application dealing with implant‐related infections caused by bacterial biofilms was demonstrated. Abstract : Implant‐related infections are a common and reoccurring problem in orthopaedic surgery . Plasma jet application could be an alternative method dealing with implant‐related infections. This in vitro study demonstrates the potential of atmospheric pressure plasma jets (kHz‐Jet and kINPen08) combining major purposes dealing with infected implants to degrade and remove the bacterial biofilm as well as simultaneously support cell development.