Palladium‐Catalyzed One‐Pot Consecutive Amination and Sonogashira Coupling for Selective Synthesis of 2‐Alkynylanilines. Issue 14 (25th September 2015)

• Record Type: Journal Article
• Authors: Pan, Shanfei; Ma, Xueji; Zhong, Danni; Chen, Wanzhi; Liu, Miaochang; Wu, Huayue
• Is Part Of: Advanced synthesis & catalysis. Volume 357:Issue 14/15(2015)
• Page Start: 3052
• Page End: 3056
• Publication Date: 2015-09-25
• Subjects: alkynols -- 2‐alkynylanilines -- norbornene -- palladium -- tandem reactions; Catalysis -- Periodicals; Organic compounds -- Synthesis -- Periodicals; Chemistry -- Periodicals; Chemistry, Technical -- Periodicals; Chemistry -- Periodicals; Catalysis -- Periodicals; Technology, Pharmaceutical -- Periodicals; 547.2
• DOI: 10.1002/adsc.201500381
• Languages: English
• ISSNs: 1615-4150

Abstract

Abstract: An efficient catalytic approach to the synthesis of N, N ‐dialkyl‐2‐alkynylanilines was developed by using Pd‐catalyzed norbornene‐mediated three‐component reactions of haloarenes, alkoxyamines (RO‐NR2 ), and alkynes. The procedure forms one CN bond and one CC bond efficiently in a one‐pot manner from readily available starting materials. A number of 2‐alkynylanilines with a broad range of functional groups were afforded in good to excellent yields. Abstract :