Protein tyrosine phosphatase 1B (PTP1B): A key regulator and therapeutic target in liver diseases. (4th November 2015)

• Record Type: Journal Article
• Authors: Chen, Pei-Jie; Cai, Shuang-Peng; Huang, Cheng; Meng, Xiao-Ming; Li, Jun
• Is Part Of: Toxicology. Volume 337(2015)
• Page Start: 10
• Page End: 20
• Publication Date: 2015-11-04
• Subjects: PTKs protein tyrosine kinases -- PTPs protein tyrosine phosphatases -- PTP1B protein tyrosine phosphatase 1B -- NAFLD non-alcoholic fatty liver disease -- HCC hepatocellular carcinoma -- DSPs dual specificity phosphatases -- LMW low molecular weight -- RPTPs transmembrane receptor-like PTPs -- NRPTPs nonreceptor-like PTPs -- MKPs mitogen-activated protein kinase phosphatases -- PRLs pTyr-specific phosphatases of regenerating liver -- PIP3 phosphatidylinositol-(3, 4, 5)-triphosphate -- LMPTP low molecular weight PTP -- PTPN1 protein tyrosine phosphatase non-receptor type1 -- ER endoplasmic reticulum -- DISC death-inducing signaling complex -- WT wild-type -- ERK extracellular signal regulated kinases -- NF-κB nuclear factor κB -- TGF-β transforming growth factor beta -- NOX NADPH oxidase -- TNF-α tumor necrosis factor-α -- IL-6 interleukin-6 -- STAT3 signal transducer and activator of transcription 3 -- HGF hepatocyte growth factor -- EGF epidermal growth factor -- PCNA proliferating cell nuclear antigen -- JNK c-Jun N-terminal kinase -- PH partial hepatectomy -- KO knockout -- SnoN ski-related novel gene -- DILI drug-induced liver disease -- ALF acute liver failure -- APAP acetaminophen -- NAPQI N-acetyl-p-benzoquinoneimine -- GSH glutathione -- IGFIR insulin-like growth factor-I receptor -- ROS reactive oxygen species -- Nrf2 nuclear factor erythroid-2-related factor 2 -- MetS metabolic syndrome -- ERS endoplasmic reticulum stress -- HFD high-fat diet -- ASO antisense oligonucleotide -- SREBP sterol regulatory element-binding protein -- FAS fatty acid synthase -- ACC acetyl-CoA carboxylase -- HMGCS1 3-hydroxy-3-methylglutaryl-coenzyme A synthase 1 -- PP2A phosphatase 2A -- IR insulin receptor -- IRS insulin receptor substrate -- PI3K phosphatidylinositol 3-kinase -- MAPK mitogen-activated protein kinase -- CHOP C/EBP homologous protein -- BIP binding immunoglobulin protein; Protein tyrosine phosphatase 1B (PTP1B) -- Liver regeneration -- Drug-induced liver disease (DILI) -- Non-alcoholic fatty liver disease (NAFLD) -- Hepatocellular carcinoma (HCC); Toxicology -- Periodicals; Chemicals -- Physiological effect -- Periodicals; 615.9005
• DOI: 10.1016/j.tox.2015.08.006
• Languages: English
• ISSNs: 0300-483X

Abstract

Abstract: Phosphorylation of tyrosine residues within proteins, which is controlled by the reciprocal action of protein tyrosine kinases and protein tyrosine phosphatases, plays a key role in regulating almost all physiological responses. Therefore, it comes as no surprise that once the balance of tyrosine phosphorylation is disturbed, drastic effects can occur. Protein tyrosine phosphatase 1B (PTP1B), a classical non-transmembrane tyrosine phosphatase, is a pivotal regulator and promising drug target in type 2 diabetes and obesity. Recently it has received renewed attention in liver diseases and represents an intriguing opportunity as a drug target by modulating hepatocyte death and survival, hepatic lipogenesis and so on. Here, the multiple roles of PTP1B in liver diseases will be presented, with respect to liver regeneration, drug-induced liver disease, non-alcoholic fatty liver disease (NAFLD) and hepatocellular carcinoma.