A curcumin activated carboxymethyl cellulose–montmorillonite clay nanocomposite having enhanced curcumin release in aqueous media. (10th December 2015)

• Record Type: Journal Article
• Authors: Madusanka, Nadeesh; de Silva, K.M. Nalin; Amaratunga, Gehan
• Is Part Of: Carbohydrate polymers. Volume 134(2015)
• Page Start: 695
• Page End: 699
• Publication Date: 2015-12-10
• Subjects: Curcumin -- Nanocomposite -- Clay -- Carboxymethylcellulose; Polysaccharides -- Periodicals; Polysaccharides -- Periodicals; Polysaccharides -- Périodiques; Electronic journals; 547.78
• DOI: 10.1016/j.carbpol.2015.08.030
• Languages: English
• ISSNs: 0144-8617

Abstract

Highlights: A novel curcumin activated MMT–CMC nanocomposite was prepared. CMC was used as an emulsifier for curcumin. MMT nanoclay acts as a matrix material while playing a role in release kinetics. Solubility of curcumin in the nanocomposite increased in the aqueous medium. Abstract: A novel curcumin activated carboxymethylcellulose–montmorillonite nanocomposite is reported. A superabsorbent biopolymer; carboxymethyl cellulose (CMC) was used as an emulsifier for curcuminwhich is a turmeric derived water insoluble polyphenolic compound with antibacterial/anti-cancer properties. Montmorillonite (MMT) nanoclay was incorporated in the formulation as a matrix material which also plays a role in release kinetics. It was observed that water solubility of curcumin in the nanocomposite has significantly increased (60% release within 2 h and 30 min in distilled water at pH 5.4) compared to pure curcumin. The prepared curcumin activated carboxymethylcellulose–montmorillonite nanocomposite is suitable as a curcumin carrier having enhanced release and structural properties.