Case study interpretation: Report from the ICCS Annual Meeting, Seattle, 2014. Issue 6 (14th May 2015)

• Record Type: Journal Article
• Authors: Fromm, Jonathan R.; Tagliente, Damian J.; Shaver, Aaron C.; Neppalli, Vishala; Craig, Fiona E.
• Is Part Of: Cytometry. Volume 88:Issue 6(2015)
• Page Start: 413
• Page End: 424
• Publication Date: 2015-05-14
• Subjects: flow cytometry -- lymphoma -- leukemia -- mixed phenotype -- plasmacytoid dendritic; Flow cytometry -- Diagnostic use -- Periodicals; Cytodiagnosis -- Periodicals; 616.07582
• DOI: 10.1002/cyto.b.21238
• Languages: English
• ISSNs: 1552-4949

Abstract

Abstract : The Case Study Interpretation (CSI) cases presented at the 2014 International Clinical Cytometry Society (ICCS) meeting in Seattle illustrate the utility of state‐of‐the art multiparameter flow cytometry in the diagnosis of hematolymphoid neoplasms. Download the listmode files (Supporting Information) and test your analysis skills before reading the case reports, keeping in mind the following questions. How many separate abnormal mature B‐cell populations can you identify, and how many of these represent different subtypes of B‐cell neoplasm? How many separate abnormal mature T‐cell populations can you identify, and do these represent different subtypes of T‐cell neoplasm or phenotypic heterogeneity in one neoplasm? How many separate immature/blastic cell populations can you identify, and do they meet criteria for mixed phenotype leukemia? Is there a population of blasts that lacks T‐cell, B‐cell, and myeloid lineage defining antigens and if so, what entities should you consider and what additional antigens should you assess for? © 2015 International Clinical Cytometry Society