An accelerated photo-magnetic imaging reconstruction algorithm based on an analytical forward solution and a fast Jacobian assembly method. (3rd October 2016)

• Record Type: Journal Article
• Authors: Nouizi, F; Erkol, H; Luk, A; Marks, M; Unlu, M B; Gulsen, G
• Is Part Of: Physics in medicine & biology. Volume 61:Number 20(2016:Oct.)
• Page Start: 7448
• Page End: 7465
• Publication Date: 2016-10-03
• Subjects: photon propagation -- photo-magnetic imaging -- diffuse optical tomography; Biophysics -- Periodicals; Medical physics -- Periodicals; 610.153
• DOI: 10.1088/0031-9155/61/20/7448
• Languages: English
• ISSNs: 0031-9155

Abstract

Abstract: We previously introduced photo-magnetic imaging (PMI), an imaging technique that illuminates the medium under investigation with near-infrared light and measures the induced temperature increase using magnetic resonance thermometry (MRT). Using a multiphysics solver combining photon migration and heat diffusion, PMI models the spatiotemporal distribution of temperature variation and recovers high resolution optical absorption images using these temperature maps. In this paper, we present a new fast non-iterative reconstruction algorithm for PMI. This new algorithm uses analytic methods during the resolution of the forward problem and the assembly of the sensitivity matrix. We validate our new analytic-based algorithm with the first generation finite element method (FEM) based reconstruction algorithm previously developed by our team. The validation is performed using, first synthetic data and afterwards, real MRT measured temperature maps. Our new method accelerates the reconstruction process 30-fold when compared to a single iteration of the FEM-based algorithm.