Long-term outcome and quality of life after initial and repeat resection of colorectal liver metastasis: A retrospective analysis. (December 2017)

• Record Type: Journal Article
• Authors: Heise, D.; Bayings, W.; Tuinhof, A.; Eickhoff, R.; Kroh, A.; Ulmer, F.; Dejong, C.H.C.; Neumann, U.; Binnebösel, M.
• Is Part Of: International journal of surgery. Volume 48(2017)
• Page Start: 281
• Page End: 285
• Publication Date: 2017-12
• Subjects: Colorectal liver metastasis -- Hepatectomy -- Quality of life; Surgery -- Periodicals; Surgical Procedures, Operative -- Periodicals; 617.005
• DOI: 10.1016/j.ijsu.2017.11.032
• Languages: English
• ISSNs: 1743-9191

Abstract

Abstract: Background: Repeat hepatectomy is a widely accepted treatment for patients with recurrent colorectal liver metastasis (CRLM). The aim of this study was to compare initial and repeat hepatic resection concerning overall survival, prognostic factors and postoperative quality of life. Methods: Data on patients who underwent initial or repeat hepatic resection for CRLM between 2010 and 2016 were prospectively collected and retrospectively evaluated. Follow-up data, EORTC QLQ-C30 and QLQ-LMC21 questionnaire results for quality of life (QoL) evaluation were analyzed. Results: 160 patients at a median age of 62.8 ± 11.8 years were analyzed. 122 were initially resected and 38 underwent a repeat hepatic resection. Disease-free survival (DSF) was superior in the initial resection group (p < 0.001), while there was no difference in overall survival (OS) (p = 0.288). BMI >30 (p = 0.012), extrahepatic tumor manifestation (p = 0.037), >1 CRLM manifestation (p = 0.009), and perioperative chemotherapy (p = 0.006) in the initial resection group and primary left colon tumor (p = 0.001) in the repeat resection group were identified as prognostic factors in multivariate Cox regression analysis. EORTC QLQ-LMC-21 module symptom score displayed an increased occurrence of a dry mouth in the initial hepatectomy group (p = 0.003). EORTC QLQ-C30 general functioning and symptom scores showed no difference. Conclusion: Repeat hepatic resection for CRLM is as effective as primary surgical treatment in terms of OS and QoL. Patients should be selected carefully concerning prognostic factors as DFS is decreased after repeat hepatic resection. Highlights: Repeat hepatic resection for colorectal liver metastasis is as effective as primary surgical treatment. Patients should be selected carefully concerning prognostic factors. Quality of life is not affected after a repeat resection.