Application of materials as medical devices with localized drug delivery capabilities for enhanced wound repair. (August 2017)

• Record Type: Journal Article
• Authors: Lee, Esther J.; Huh, Beom Kang; Kim, Se Na; Lee, Jae Yeon; Park, Chun Gwon; Mikos, Antonios G.; Choy, Young Bin
• Is Part Of: Progress in materials science. Volume 89(2017)
• Page Start: 392
• Page End: 410
• Publication Date: 2017-08
• Subjects: AASF Antheraea assama silk fibroin -- BC benzalkonium chloride -- BMP-2 bone morphogenetic protein-2 -- β-TCP β-tricalcium phosphate -- CDDP cis-diamminedichloroplatinum -- CMC carboxymethylcellulose -- E. coli Escherichia coli -- EGF epidermal growth factor -- FGF-2 fibroblast growth factor-2 -- hGH human growth hormone -- HA hydroxyapatite -- IGF-1 insulin-like growth factor-1 -- MIC minimum inhibitory concentration -- MRSA methicillin-resistant Staphylococcus aureus -- NSAID nonsteroidal anti-inflammatory drug -- P. aeruginosa Pseudomonas aeruginosa -- PCL poly(ε-caprolactone) -- PDLLA poly(d, l-lactic acid) -- PDX poly(dioxanone) -- PE poly(ethylene) -- PEG poly(ethylene glycol) -- PEI poly(ethyleneimine) -- PEMA poly(ethylmethacrylate) -- PGA poly(glycolic acid) -- PGC poly(glyconate) -- PGL poly(glactin) -- PLA poly(lactic acid) -- PLGA poly(lactic-co-glycolic acid) -- PLA-DX-PEG poly(d, l-lactic acid)-poly(p-dioxanone)-poly(ethylene glycol) -- PLDLLA poly(l, dl-lactic acid) -- PLLA poly(l-lactic acid) -- PMMA poly(methylmethacrylate) -- PNIPAAm poly(N-isopropylacrylamide) -- PTMC poly(trimethylene carbonate) -- PU polyurethane -- PVA poly(vinyl alcohol) -- S. aureus Staphylococcus aureus -- S. epidermidis Staphylococcus epidermidis -- TGF-β1 transforming growth factor-β1 -- TNT titania nanotube; Material -- Medical device -- Wound repair -- Drug delivery; Materials science -- Periodicals; Science des matériaux -- Périodiques; 620.1105
• DOI: 10.1016/j.pmatsci.2017.06.003
• Languages: English
• ISSNs: 0079-6425

Abstract

Abstract: The plentiful assortment of natural and synthetic materials can be leveraged to accommodate diverse wound types, as well as different stages of the healing process. An ideal material is envisioned to promote tissue repair with minimal inconvenience for patients. Traditional materials employed in the clinical setting often invoke secondary complications, such as infection, pain, foreign body reaction, and chronic inflammation. This review surveys the repertoire of surgical sutures, wound dressings, surgical glues, orthopedic fixation devices and bone fillers with drug eluting capabilities. It highlights the various techniques developed to effectively incorporate drugs into the selected material or blend of materials for both soft and hard tissue repair. The mechanical and chemical attributes of the resultant materials are also discussed, along with their biological outcomes in vitro and/or in vivo . Perspectives and challenges regarding future research endeavors are also delineated for next-generation wound repair materials.