Synthesis of deuterium‐labeled 2‐quinoxalinecarboxylic acid and 3‐methylquinoxaline‐2‐carboxylic acid from deuterium aniline. (2nd September 2018)

• Record Type: Journal Article
• Authors: Chen, Wulian; Zhao, Chaomin; Deng, Xiaojun
• Is Part Of: Journal of labelled compounds & radiopharmaceuticals. Volume 61:Number 14(2018)
• Page Start: 1043
• Page End: 1047
• Publication Date: 2018-09-02
• Subjects: 2‐quinoxalinecarboxylic acid‐d4 -- 3‐methylquinoxaline‐2‐carboxylic acid‐d4 -- aniline‐d5 -- synthesis; Tracers (Chemistry) -- Periodicals; Radiopharmaceuticals -- Periodicals; 615.8424
• DOI: 10.1002/jlcr.3679
• Languages: English
• ISSNs: 0362-4803

Abstract

Abstract : An efficient and simple synthetic route of deuterium‐labeled 2‐quinoxalinecarboxylic acid‐ d 4 (QCA‐ d 4 ) and 3‐methylquinoxaline‐2‐carboxylic acid‐ d 4 (MQCA‐ d 4 ) is presented with 99.9% and 99.6% isotopic enrichment using aniline‐ d 5 as labeled starting material. Their chemical structures were confirmed by 1 H NMR, and their isotopic abundance was determined by mass spectrometry analysis. Abstract : An efficient and simple synthetic route of deuterium‐labelled 2‐quinoxalinecarboxylic acid‐ d 4 (QCA‐ d 4 ) and 3‐methylquinoxaline‐2‐carboxylic acid‐ d 4 (MQCA‐ d 4 ) is presented. Their chemical structures were confirmed by 1 H NMR, and their isotopic abundance was determined by mass spectrometry analysis.