Miglitol attenuates non‐alcoholic steatohepatitis in diabetic patients. Issue 13 (27th July 2018)
- Record Type:
- Journal Article
- Title:
- Miglitol attenuates non‐alcoholic steatohepatitis in diabetic patients. Issue 13 (27th July 2018)
- Main Title:
- Miglitol attenuates non‐alcoholic steatohepatitis in diabetic patients
- Authors:
- Komatsu, Michiharu
Tanaka, Naoki
Kimura, Takefumi
Fujimori, Naoyuki
Sano, Kenji
Horiuchi, Akira
Sugiura, Ayumi
Yamazaki, Tomoo
Shibata, Soichiro
Joshita, Satoru
Umemura, Takeji
Matsumoto, Akihiro
Tanaka, Eiji - Abstract:
- Abstract : Aim: Postprandial hyperglycemia is frequently accompanied by non‐alcoholic fatty liver disease (NAFLD) and steatohepatitis (NASH). Although α‐glucosidase inhibitors (αGIs) can slow glucose absorption from the intestine and suppress the surge of circulating glucose concentration after meals, it remains unclear whether αGIs are also beneficial for NASH. The aim of this prospective study was to examine the efficacy and safety of miglitol, a typical αGI, for NASH. Methods: Seventeen patients with histologically confirmed NASH and hemoglobin A1c (HbA1c) >6.5% were treated with miglitol (150 mg/day) for 12 months. The changes in clinical parameters and liver histology were analyzed. Results: All patients completed the 12‐month miglitol treatment course with no severe adverse events. The treatment significantly decreased body mass index, serum alanine aminotransferase levels, and HbA1c (all P < 0.001). Post‐treatment liver biopsy of 11 patients revealed significant improvements in steatosis (from 2.2 ± 0.6 to 1.5 ± 0.7, P = 0.001), lobular inflammation (from 1.8 ± 0.8 to 1.3 ± 0.5, P = 0.014), portal inflammation scores (from 0.6 ± 0.5 to 0.1 ± 0.3, P = 0.025), and NAFLD activity score (from 5.5 ± 1.5 to 3.9 ± 1.4, P = 0.012). Fibrosis and hepatocyte ballooning scores were unchanged. Conclusions: Miglitol appears to safely ameliorate NASH activity by attenuation of steatosis and lobular/portal inflammation. Appropriately powered controlled trials are warranted toAbstract : Aim: Postprandial hyperglycemia is frequently accompanied by non‐alcoholic fatty liver disease (NAFLD) and steatohepatitis (NASH). Although α‐glucosidase inhibitors (αGIs) can slow glucose absorption from the intestine and suppress the surge of circulating glucose concentration after meals, it remains unclear whether αGIs are also beneficial for NASH. The aim of this prospective study was to examine the efficacy and safety of miglitol, a typical αGI, for NASH. Methods: Seventeen patients with histologically confirmed NASH and hemoglobin A1c (HbA1c) >6.5% were treated with miglitol (150 mg/day) for 12 months. The changes in clinical parameters and liver histology were analyzed. Results: All patients completed the 12‐month miglitol treatment course with no severe adverse events. The treatment significantly decreased body mass index, serum alanine aminotransferase levels, and HbA1c (all P < 0.001). Post‐treatment liver biopsy of 11 patients revealed significant improvements in steatosis (from 2.2 ± 0.6 to 1.5 ± 0.7, P = 0.001), lobular inflammation (from 1.8 ± 0.8 to 1.3 ± 0.5, P = 0.014), portal inflammation scores (from 0.6 ± 0.5 to 0.1 ± 0.3, P = 0.025), and NAFLD activity score (from 5.5 ± 1.5 to 3.9 ± 1.4, P = 0.012). Fibrosis and hepatocyte ballooning scores were unchanged. Conclusions: Miglitol appears to safely ameliorate NASH activity by attenuation of steatosis and lobular/portal inflammation. Appropriately powered controlled trials are warranted to validate our results. … (more)
- Is Part Of:
- Hepatology research. Volume 48:Issue 13(2018)
- Journal:
- Hepatology research
- Issue:
- Volume 48:Issue 13(2018)
- Issue Display:
- Volume 48, Issue 13 (2018)
- Year:
- 2018
- Volume:
- 48
- Issue:
- 13
- Issue Sort Value:
- 2018-0048-0013-0000
- Page Start:
- 1092
- Page End:
- 1098
- Publication Date:
- 2018-07-27
- Subjects:
- alpha‐glucosidase inhibitor -- fibrosis -- lobular inflammation -- non‐alcoholic steatohepatitis -- steatosis
Liver -- Diseases -- Periodicals
Liver Diseases -- Periodicals
Foie -- Maladies -- Périodiques
616.362 - Journal URLs:
- http://www.sciencedirect.com/science/journal/09284346 ↗
http://firstsearch.oclc.org/journal=1386-6346;screen=info;ECOIP ↗
http://onlinelibrary.wiley.com/journal/10.1111/(ISSN)1872-034X ↗
http://www.sciencedirect.com/science/journal/13866346 ↗
http://www3.interscience.wiley.com/journal/118507311/home ↗
http://www.blackwell-synergy.com/rd.asp?goto=journal&code=hep ↗
http://onlinelibrary.wiley.com/ ↗ - DOI:
- 10.1111/hepr.13223 ↗
- Languages:
- English
- ISSNs:
- 1386-6346
- Deposit Type:
- Legaldeposit
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- Available online (eLD content is only available in our Reading Rooms) ↗
- Physical Locations:
- British Library DSC - 4295.845000
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