Recent advances in Barrett's esophagus. Issue 1 (5th July 2018)

• Record Type: Journal Article
• Authors: Inadomi, John; Alastal, Hani; Bonavina, Luigi; Gross, Seth; Hunt, Richard H.; Mashimo, Hiroshi; di Pietro, Massimiliano; Rhee, Horace; Shah, Marmy; Tolone, Salvatore; Wang, David H.; Xie, Shao‐Hua
• Other Names: Giuli Robert guestEditor.
• Is Part Of: Annals of the New York Academy of Sciences. Volume 1434:Issue 1(2018)
• Page Start: 227
• Page End: 238
• Publication Date: 2018-07-05
• Subjects: Barrett's esophagus -- esophageal adenocarcinoma -- screening -- surveillance -- endoscopy -- imaging; Medical sciences -- Periodicals; Medicine -- Periodicals; Science -- Periodicals; 610
• DOI: 10.1111/nyas.13909
• Languages: English
• ISSNs: 0077-8923

Abstract

Abstract: Barrett's esophagus (BE) is the only known precursor of esophageal adenocarcinoma, one of the few cancers with increasing incidence in developed countries. The pathogenesis of BE is unclear with regard to either the cellular origin of this metaplastic epithelium or the manner in which malignant transformation occurs, although recent data indicate a possible junctional origin of stem cells for BE. Treatment of BE may be achieved using endoscopic eradication therapy; however, there is a lack of discriminatory tools to identify individuals at sufficient risk for cancer development in whom intervention is warranted. Reduction in gastroesophageal reflux of gastric contents including acid is mandatory to achieve remission from BE after endoscopic ablation, and can be achieved using medical or nonmedical interventions. Research topics of greatest interest include the mechanism of BE development and transformation to cancer, risk stratification methods to identify individuals who may benefit from ablation of BE, optimization of eradication therapy, and surveillance methods to ensure that remission is maintained after eradication is achieved. Abstract : Barrett's esophagus (BE) is defined as the replacement of the normal squamous lining of the esophagus with columnar epithelium (intestinal metaplasia) and is the only known precursor for the development of esophageal adenocarcinoma (EAC). Our review stems from the discussion of topics in BE at the 14th OESO World Conference: Global perspectives in Esophageal disease, and examines emerging data about the pathogenesis, screening and surveillance strategies, and treatment options for individuals with BE.