Preclinical models for the study of Barrett's carcinogenesis. Issue 1 (5th July 2018)

• Record Type: Journal Article
• Authors: Read, Matthew D.; Krishnadath, Kausilia K.; Clemons, Nicholas J.; Phillips, Wayne A.
• Other Names: Giuli Robert guestEditor.
• Is Part Of: Annals of the New York Academy of Sciences. Volume 1434:Issue 1(2018)
• Page Start: 139
• Page End: 148
• Publication Date: 2018-07-05
• Subjects: Barrett's esophagus -- reflux models -- transgenic models -- organoid -- preclinical model -- animal models; Medical sciences -- Periodicals; Medicine -- Periodicals; Science -- Periodicals; 610
• DOI: 10.1111/nyas.13916
• Languages: English
• ISSNs: 0077-8923

Abstract

Abstract: Barrett's esophagus (BE) is clinically significant, as it is the only known precursor lesion for esophageal adenocarcinoma. To develop improved therapies for the treatment of BE, a greater understanding of the disease process at the molecular genetic level is needed. However, achieving a greater understanding will require improved preclinical models so that the disease process can be more closely studied and novel therapies can be tested. Our concise review highlights progress in the development of preclinical models for the study of BE and identifies the most suitable model in which to test novel therapies.