Oxidative stress and dietary phytochemicals: Role in cancer chemoprevention and treatment. (28th January 2018)

• Record Type: Journal Article
• Authors: Chikara, Shireen; Nagaprashantha, Lokesh Dalasanur; Singhal, Jyotsana; Horne, David; Awasthi, Sanjay; Singhal, Sharad S.
• Is Part Of: Cancer letters. Volume 413(2018)
• Page Start: 122
• Page End: 134
• Publication Date: 2018-01-28
• Subjects: Carcinogenesis -- Chemoprevention -- Chemotherapy -- Oxidative stress -- Nrf2 -- Phytochemicals; AKT protein kinase B -- AMPK AMP-activated protein kinase -- ARE antioxidant response element -- ATF-2 activating transcriptional factor -- BBN N-butyl-N-(4-hydroxybutyl)nitrosamine -- CAF cancer-associated fibroblasts -- CDDP cisplatin -- CYPs cytochrome P450s -- COX-2 cyclooxygenase-2 -- CXCR4 chemokine receptor -- DMBA 7, 12-dimethylbenz(a)anthracene -- EGCG epigallocatechin gallate -- EMT epithelial-to-mesenchymal transition -- EpRE electrophile response element -- ERK extracellular signal regulated kinase -- γH2AX phosphorylated H2AX -- Glut-1 glucose transporter-1 -- GPx glutathione peroxidase -- GS-E glutathione-electrophile conjugate -- GSH reduced glutathione -- GS-HNE GSH-4-hydroxy-t-2, 3-nonenal conjugate -- GSSG oxidized glutathione -- GST glutathione-S-transferase -- 2HF 2′-hydroxyflavanone -- 4-OHE2 4-hydroxyestradiol -- 4HNE 4-hydroxynonenal -- HGF hepatocyte growth factor -- Hh hedgehog -- H2O2 hydrogen peroxide -- HMOX-1 heme oxygenase-1 -- ICAM-1 intercellular adhesion molecule-1 -- iNOS inducible nitric oxide synthase -- JAK janus kinase -- KEAP kelch-like erythroid Cap'n'Collar homologue-associated protein -- KRAS kirsten rat sarcoma -- MAOA monoamine oxidase A -- MAPK mitogen activated protein kinase -- MMP matrix metalloproteinase -- NAC N-acetylcysteine -- NFkB nuclear factor-kappa B -- 3NT 3-nitrotyrosine -- NNK 4-(methylnitosamino)-1-(3-pyridyl)-1-butanone -- ND6 NADH dehydrogenase subunit 6 -- NOX5 NADPH oxidase 5 -- NQO1 NAD(P)H: quinone oxidoreductase 1 -- Nrf2 nuclear factor-E2 -- NUDT1 nucleoside diphosphate linked moiety X-type motif 1 -- OH· hydroxyl radicals -- 8-OHdG 8-oxo-2′-deoxyguanosine -- O2− superoxide anion -- OGG1 8-oxoguanine DNA Glycosylase -- PAH polycyclic aromatic hydrocarbon -- PEITC phenethyl isothiocyanate -- PhIP 2-amino-1-methyl-6-phenylimidazo[4, 5-b]pyridine -- PARP poly (ADP-ribose) polymerase -- PI3K phosphatidylinositol-3 kinase -- PKC protein kinase c -- PMBC peripheral blood mononuclear cells -- PRDx peroxiredoxins -- QR quinine reductase -- RLIP76 ral-interacting protein -- ROS reactive oxygen species -- siRNA small-interfering RNA -- SOD superoxide dismutase -- STAT signal transducer and activator of transcription -- TP53 tumor suppressor 53 -- TRXR thioredoxin reductase -- TXN thioredoxins -- uPA urokinase-type plasminogen activator -- UGT UDP-glucuronosyltransferases; Cancer -- Periodicals; Neoplasms -- Periodicals; Cancer -- Périodiques; Electronic journals; 616.994
• DOI: 10.1016/j.canlet.2017.11.002
• Languages: English
• ISSNs: 0304-3835

Abstract

Abstract: Several epidemiological observations have shown an inverse relation between consumption of plant-based foods, rich in phytochemicals, and incidence of cancer. Phytochemicals, secondary plant metabolites, via their antioxidant property play a key role in cancer chemoprevention by suppressing oxidative stress-induced DNA damage. In addition, they modulate several oxidative stress-mediated signaling pathways through their anti-oxidant effects, and ultimately protect cells from undergoing molecular changes that trigger carcinogenesis. In several instances, however, the pro-oxidant property of these phytochemicals has been observed with respect to cancer treatment. Further, in vitro and in vivo studies show that several phytochemicals potentiate the efficacy of chemotherapeutic agents by exacerbating oxidative stress in cancer cells. Therefore, we reviewed multiple studies investigating the role of dietary phytochemicals such as, curcumin (turmeric), epigallocatechin gallate (EGCG; green tea), resveratrol (grapes), phenethyl isothiocyanate (PEITC), sulforaphane (cruciferous vegetables), hesperidin, quercetin and 2′-hydroxyflavanone (2HF; citrus fruits) in regulating oxidative stress and associated signaling pathways in the context of cancer chemoprevention and treatment. Highlights: Review of the role of oxidative stress in carcinogenesis and in promoting resistance to chemotherapeutic drugs. Antioxidant and pro-oxidant potential of plant-derived phytochemicals in different cancer types. Potential of phytochemicals in regulating oxidative stress associated signaling pathways in cancer. Assessment of the ability of phytochemicals to potentiate anticancer efficacy of chemotherapeutic drugs.