Cup-like Blasts in 2 Pediatric Patients With NPM-1-Positive Acute Myeloid Leukemia. Issue 4 (May 2018)

• Record Type: Journal Article
• Authors: Tüfekçi, Özlem; Erdem, Melek; Ören, Hale; Yilmaz, Şebnem
• Is Part Of: Journal of pediatric hematology/oncology. Volume 40:Issue 4(2018)
• Publication Date: 2018-05
• Subjects: acute myeloid leukemia -- cup-like blast -- Npm-1; Pediatric hematology -- Periodicals; Tumors in children -- Periodicals; 618.9215
• DOI: 10.1097/MPH.0000000000001110
• Languages: English
• ISSNs: 1077-4114

Abstract

Abstract : Cup-like phenotype is defined in some subtypes of acute myeloid leukemia (AML) and have been associated with NPM-1 and/or FLT3-ITD positivity in the presence of normal karyotype in >60% of patients. Herein we present two pediatric AML-M1 patients with cuplike nuclear morphology and NPM-1 positivity. Both patients were negative for FLT3-ITD mutation. NPM-1 mutation and FLT3-ITD mutation should be kept in mind in AML patients with cup-like blast morphology as these two mutations are important molecular markers for prognosis, risk group classification and also for response to treatment.