UV-crosslinkable and thermo-responsive chitosan hybrid hydrogel for NIR-triggered localized on-demand drug delivery. (15th October 2017)

• Record Type: Journal Article
• Authors: Wang, Lei; Li, Baoqiang; Xu, Feng; Xu, Zheheng; Wei, Daqing; Feng, Yujie; Wang, Yaming; Jia, Dechang; Zhou, Yu
• Is Part Of: Carbohydrate polymers. Volume 174(2017)
• Page Start: 904
• Page End: 914
• Publication Date: 2017-10-15
• Subjects: UV-crosslinkable chitosan -- Thermo-responsive hydrogel -- In situ forming hydrogel -- Photothermal carbon -- NIR-triggered localized on-demand drug release; Polysaccharides -- Periodicals; Polysaccharides -- Periodicals; Polysaccharides -- Périodiques; Electronic journals; 547.78
• DOI: 10.1016/j.carbpol.2017.07.013
• Languages: English
• ISSNs: 0144-8617

Abstract

Graphical abstract: Highlights: UV-crosslinkable and thermo-responsive chitosan was designed and synthesized. NIR-triggered switchable swelling/shrinking behavior (∼42% shrinkage). NIR-triggered drug release rate was boosted by 40 times. Smart injectable hydrogel allows NIR-triggered localized on-demand drug delivery. Abstract: Innovative drug delivery technologies based on smart hydrogels for localized on-demand drug delivery had aroused great interest. To acquire smart UV-crosslinkable chitosan hydrogel for NIR-triggered localized on-demanded drug release, a novel UV-crosslinkable and thermo-responsive chitosan was first designed and synthesized by grafting with poly N -isopropylacrylamide, acetylation of methacryloyl groups and embedding with photothermal carbon. The UV-crosslinkable unit (methacryloyl groups) endowed chitosan with gelation via UV irradiation. The thermo-responsive unit (poly N -isopropylacrylamide) endowed chitosan hydrogel with temperature-triggered volume shrinkage and reversible swelling/de-swelling behavior. The chitosan hybrid hydrogel embedded with photothermal carbon exhibited distinct NIR-triggered volume shrinkage (∼42% shrinkage) in response to temperature elevation as induced by NIR laser irradiation. As a demonstration, doxorubicin release rate was accelerated and approximately 40 times higher than that from non-irradiated hydrogels. The UV-crosslinkable and thermal-responsive hybrid hydrogel served as in situ forming hydrogel-based drug depot is developed for NIR-triggered localized on-demand release.