Highly photostable, lysosome-targeted BODIPYs with green to near-infrared emission for lysosome imaging in living cells. (August 2018)

• Record Type: Journal Article
• Authors: Ye, Zhuo; Xiong, Chao; Pan, Jian; Su, Dongdong; Zeng, Lintao
• Is Part Of: Dyes and pigments. Volume 155(2018)
• Page Start: 30
• Page End: 35
• Publication Date: 2018-08
• Subjects: BODIPY -- Photostable -- Lysosome-targeted -- Imaging -- Fluorescence; Dyes and dyeing -- Periodicals; Pigments -- Periodicals; 667.2
• DOI: 10.1016/j.dyepig.2018.03.015
• Languages: English
• ISSNs: 0143-7208

Abstract

Abstract: A series of highly photostable, lysosome-targeted BODIPYs with tunable fluorescence from green to the near-infrared region was developed. The probes were found to show an accurate lysosome-targeting ability with high selectivity and high photostability under continuous excitation irradiation. The results show that these lysosome-targeted BODIPYs offer a simple and convenient tool for fluorescence imaging of lysosomes, which will be valuable for understanding the activity and function of lysosomes in related cells. Graphical abstract: Highlights: BODIPY derivatives with green to near-infrared emission are developed. The optical properties of BODIPY derivatives are investigated. BODIPY derivatives show highly photostable properties in vitro and in live cells. BODIPY derivatives show an accurate lysosome-targeting ability with high selectivity.